Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Using individual biomarkers to improve lymphoma treatment

Official title: Interest of Individual Biomarkers From the Identification of Tumor Genotype in Plasma (ctDNA: Circulating Tumor DNA) by High-throughput Molecular Next Generation Techniques(CAPP Seq, PhAsE Seq, VIRCAPP-seq) in the Diagnosis and Personalized Management of Lymphomas in a Prospective Monocentric Cohort

Run by Centre Hospitalier Universitaire Dijon · NCT04417803 · Data updated 2026-11-12

This study is testing if using individual blood tests and imaging can help doctors create better treatment plans for people with certain types of lymphoma.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment1200 (estimated)
SponsorCentre Hospitalier Universitaire Dijon
Academic / other
Locations1 site (Dijon)
StatusRecruiting
StartedMay 17, 2021
Main results expectedMay 2046
Study endsMay 2046
Registry record updatedJune 11, 2025
Trial IDNCT04417803 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults diagnosed with diffuse large B-cell lymphoma, Hodgkin's lymphoma, or follicular lymphoma who are not currently undergoing treatment.

Probably not a fit

Patients with localized lymphoma that has been treated surgically or with localized radiotherapy may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on patients diagnosed with specific types of lymphomas, including diffuse large B-cell lymphoma, Hodgkin's lymphoma, and follicular lymphoma. It aims to enhance treatment strategies by utilizing high-throughput molecular techniques to identify tumor genotypes and individual biomarkers. The approach involves blood sampling and the use of PET imaging to optimize treatment plans based on patient responses. By integrating these methods, the study seeks to improve patient management and outcomes during and after treatment.

Why it matters

Potential benefit: If successful, this study could lead to more personalized and effective treatment strategies for lymphoma patients.

How similar studies have gone: Other studies have shown promise in using molecular techniques and PET imaging for personalized treatment approaches in lymphomas, indicating a potential for success in this area.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Person who has not opposed to their inclusion in the trial
* Confirmation of the diagnosis of one of the lymphomas (DGLBL, LF, classic LH, LT or LCM) according to the WHO 2016 international classification (Smerdlow et al, 2016)
* Patients not currently taking treatment for their haemopathy (or who have received corticosteroid therapy alone within 14 days prior to the 1st sampling, dose limited to 500mg total)
* Patients requiring systemic treatment within 30 days of screening

Exclusion Criteria:

* Person subject to legal protection (curatorship, guardianship)
* Person under partial judicial control
* Pregnant, parturient or breastfeeding woman
* Adult incapable or incapable to express his or her non-opposition
* Minor
* Localized lymphoma treated by surgery and/or localized radiotherapy

Where it's running

  • Chu Dijon Bourgogne
    Dijon, France
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.