Using individual biomarkers to improve lymphoma treatment
Official title: Interest of Individual Biomarkers From the Identification of Tumor Genotype in Plasma (ctDNA: Circulating Tumor DNA) by High-throughput Molecular Next Generation Techniques(CAPP Seq, PhAsE Seq, VIRCAPP-seq) in the Diagnosis and Personalized Management of Lymphomas in a Prospective Monocentric Cohort
Run by Centre Hospitalier Universitaire Dijon · NCT04417803 · Data updated 2026-11-12
This study is testing if using individual blood tests and imaging can help doctors create better treatment plans for people with certain types of lymphoma.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1200 (estimated) |
| Sponsor | Centre Hospitalier Universitaire Dijon Academic / other |
| Locations | 1 site (Dijon) |
| Status | Recruiting |
| Started | May 17, 2021 |
| Main results expected | May 2046 |
| Study ends | May 2046 |
| Registry record updated | June 11, 2025 |
| Trial ID | NCT04417803 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults diagnosed with diffuse large B-cell lymphoma, Hodgkin's lymphoma, or follicular lymphoma who are not currently undergoing treatment.
✕Probably not a fit
Patients with localized lymphoma that has been treated surgically or with localized radiotherapy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study focuses on patients diagnosed with specific types of lymphomas, including diffuse large B-cell lymphoma, Hodgkin's lymphoma, and follicular lymphoma. It aims to enhance treatment strategies by utilizing high-throughput molecular techniques to identify tumor genotypes and individual biomarkers. The approach involves blood sampling and the use of PET imaging to optimize treatment plans based on patient responses. By integrating these methods, the study seeks to improve patient management and outcomes during and after treatment.
Why it matters
Potential benefit: If successful, this study could lead to more personalized and effective treatment strategies for lymphoma patients.
How similar studies have gone: Other studies have shown promise in using molecular techniques and PET imaging for personalized treatment approaches in lymphomas, indicating a potential for success in this area.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Person who has not opposed to their inclusion in the trial * Confirmation of the diagnosis of one of the lymphomas (DGLBL, LF, classic LH, LT or LCM) according to the WHO 2016 international classification (Smerdlow et al, 2016) * Patients not currently taking treatment for their haemopathy (or who have received corticosteroid therapy alone within 14 days prior to the 1st sampling, dose limited to 500mg total) * Patients requiring systemic treatment within 30 days of screening Exclusion Criteria: * Person subject to legal protection (curatorship, guardianship) * Person under partial judicial control * Pregnant, parturient or breastfeeding woman * Adult incapable or incapable to express his or her non-opposition * Minor * Localized lymphoma treated by surgery and/or localized radiotherapy
Where it's running
-
Chu Dijon Bourgogne
Dijon, France Recruiting
Study contacts
- Study coordinator: Cédric ROSSI
- Email: cedric.rossi@chu-dijon.fr
- Phone: 0380295041
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.