Using Impulse Oscillometry to Diagnose Asthma and COPD in Patients Over 40

The Application of Impulse Oscillometry on the Differential Diagnosis of ACOS,Asthma and COPD.

This study is testing a new breathing test to see if it can help doctors tell the difference between asthma and COPD in people over 40.

Quick facts

• Study type: Observational
• Enrollment: 100 (estimated)
• Ages: 40 Years to 90 Years
• Sex: All
• Sponsor: Shengjing Hospital (other)
• Locations: 1 site (Shenyang, Liaoning)
• Trial ID: NCT03181152 on ClinicalTrials.gov

What this trial studies

This study assesses the effectiveness of Impulse Oscillometry (IOS) in differentiating between Asthma-COPD Overlap Syndrome (ACOS), asthma, and chronic obstructive pulmonary disease (COPD) in patients aged 40 and older. IOS is a non-invasive method that measures respiratory impedance during tidal breathing, allowing for the identification of airway obstruction and responses to bronchodilators. Participants will undergo an IOS test followed by inhalation of salbutamol, with subsequent measurements taken to analyze the data. The goal is to provide distinct impedance profiles for each condition to improve diagnostic accuracy.

Who should consider this trial

Good fit: Ideal candidates are individuals over 40 years old with symptoms indicative of ACOS, asthma, or COPD.

Not a fit: Patients under 40 years old or those without respiratory symptoms may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could lead to more accurate diagnoses and better management of respiratory conditions for patients.

How similar studies have performed: While the use of IOS is gaining traction, this specific application for differential diagnosis among these conditions is relatively novel.

Eligibility criteria

Inclusion Criteria:

- 1.1 ACOS:

1. Patient is older than 40 years old.
2. There are characteristics of bronchial asthma and COPD.
3. There is a history of exposure to risk factors.
4. Existence of persistent airflow limitation: After the application of bronchodilators, FEV1/FVC\<0.7, and lung function proved reversible exhalation.
5. The existence of reversible airflow limitation: Bronchial Dilation Test positive.

1.2Asthma: 1)Patient is older than 40 years old. 2)History of reversible respiratory symptoms. 3) non-smokers. 4)lung function:At least one time proved that the airflow limitation: Bronchial Dilation Test positive.

5)previously diagnosed asthma. 1.3COPD:

1. Patient is older than 40 years old.
2. Complaints about dyspnea, chronic cough or expectoration.
3. There is a history of exposure to risk factors.
4. Existence of persistent airflow limitation: After the application of bronchodilators, FEV1/FVC\<0.7.
5. The existence of irreversible airflow limitation: Bronchial Dilation Test negative.

Exclusion Criteria:

- 2.1 Combining other respiratory diseases that affect airflow,such as lung cancer, tuberculosis, pneumonia and bronchiectasis.

2.2 At the time doing lung function test, the factors that affect the airflow limitation are not stopped or just stopped with the time interval not long enough to meet the test standard.

2.3 Using special accompanying medication. For example, patients with drugs such as glucocorticoid.

Where this trial is running

Shenyang, Liaoning

• Shenjing Hospital — Shenyang, Liaoning, China (RECRUITING)

Study contacts

• Study coordinator: YIZHUO GAO, Master

Conditions: Asthma-COPD Overlap Syndrome, Asthma, COPD, Diagnoses Disease