Using imaging to predict cancer response in rectal cancer patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the effectiveness of amide proton transfer-weighted imaging in predicting the pathological complete response of rectal cancer patients after they have undergone neoadjuvant therapy. Participants will receive this imaging technique as part of their routine MRI examinations to assess how well their cancer responds before surgical intervention. The study focuses on patients with locally advanced rectal cancer who are eligible for surgery following neoadjuvant treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Locally advanced rectal cancer(cT3-4, or cN+), resectable, histologically confirmed rectal adenocarcinoma
* Received neoadjuvant therapy before surgery
* Complete radical resection of rectal cancer and postoperative pathological examination
* Informed consent and signed the informed consent form

Exclusion Criteria:

* Poor image quality, such as severe artifacts
* Complicated with intestinal obstruction, intestinal perforation and other cases requiring surgical treatment
* The interval between preoperative MRI and surgery was more than 2 weeks
* Prior treatment for rectal cancer
* History of other malignant tumors
* Patients who cannot undergo MRI examination due to contraindications or relative contraindications
* Patients were lost to follow-up or voluntarily withdrew from the study due to adverse reactions or other reasons

Where it's running

• Sixth Affiliated Hospital, Sun Yat-sen University
  Guangzhou, Guangdong, China Recruiting
• Xinyi People's Hospital
  Maoming, Guangdong, China Not yet recruiting

Study contacts

• Study coordinator: Peiyi Xie
• Email: xiepy6@mail.sysu.edu.cn
• Phone: 86+13724071514

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.