Using ihMT MRI to assess myelin disruption in multiple sclerosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to develop in vivo biomarkers that can effectively monitor demyelination and remyelination processes in patients with multiple sclerosis (MS). The study utilizes a novel imaging technique called inhomogeneous Magnetisation Transfer (ihMT), which has shown promise in preliminary studies for its sensitivity in evaluating myelin disruption. By focusing on patients with early relapsing-remitting MS, the study seeks to measure and describe the spontaneous demyelination and remyelination processes involved in active lesions. Participants will undergo MRI scans to assess these processes over time.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* For Patients and Controls :

  * Adult patient, male and female, age 18 to 45
  * Patient affiliated with health insurance coverage,
  * Patient who signed a free and informed consent after receiving detailed, understandable and honest information,
* For patients only :

  * Patient with relapsing-remitting multiple sclerosis according to the McDonald 2010 criteria or progressive
  * Patients treated or not treated with first-line disease modifying therapy
  * Detection of at least one post-Gadolinium injection active lesion identified on the initial brain MRI (T0) or a chronic active lesion (PRL: Paramagnetic rim lesions)

Exclusion Criteria:

* For patients only :

  • Patients with a progressive form of MS other than the early relapsing-remitting form (primary progressive or secondary progressive)
* For Patients and Controls :

  * Patients with the usual contraindications for MRI (pacemaker, agitation, metal shards, claustrophobia)
  * Patients at risk of non-compliance to the exam: basic problems with understanding, confusion, involuntary movements, poor tolerance of prolonged supine position
  * Patients who are unable to give their consent: problems with understanding, lack of vigilance, confusion
  * Woman who is pregnant and breastfeeding
  * Patients with a history of neurological or psychiatric condition
  * Patients under guardianship or trusteeship

Where it's running

• Assistance Publique Des Hotipaux de Marseille
  Marseille, Paca, France Recruiting

Study contacts

• Study coordinator: Jean Pelletier, Md
• Email: Jean.PELLETIER@ap-hm.fr
• Phone: +33 491388204

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.