Using IGF-1 to improve bone healing in dental defects
Efficacy of Insulin Like Growth Factor-1(IGF-1) on Bone Regeneration in Intrabony Defects : A Clinico-radiograph Study
NA · SVS Institute of Dental Sciences · NCT06426524
This study is testing if a gel made with IGF-1 can help patients with gum disease heal their bone better than just using a standard treatment.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 24 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | SVS Institute of Dental Sciences (other) |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Hyderabad, Telangana) |
| Trial ID | NCT06426524 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of Insulin Like Growth Factor-1 (IGF-1) in promoting bone regeneration in patients with intrabony periodontal defects. Participants will be divided into two groups: one receiving IGF-1 gel combined with hydroxyapatite, and the other receiving only hydroxyapatite. The study will assess clinical outcomes and radiographic changes to determine the efficacy of IGF-1 in enhancing bone healing. The methodology includes flap reflection, degranulation, and placement of the treatment in the defect site.
Who should consider this trial
Good fit: Ideal candidates are systemically healthy adults over 18 years with specific types of intrabony defects and probing pocket depths greater than 5mm.
Not a fit: Patients who are medically compromised, pregnant, heavy smokers, or have undergone radiotherapy or chemotherapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could significantly enhance bone regeneration in patients with periodontal defects, leading to improved dental health.
How similar studies have performed: While the use of IGF-1 in bone regeneration is promising, this specific approach in periodontal defects is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Systemically healthy male and female patients of age \>18 years Intrabony defects - two wall or three wall defects Probing pocket depths (PPD) of \>5mm. Exclusion Criteria: Medically compromised patients Pregnant women Heavy smokers Patients who underwent radiotherapy or chemotherapy are excluded
Where this trial is running
Hyderabad, Telangana
- SVS Institute of Dental Sciences, Mahabubnagar — Hyderabad, Telangana, India (RECRUITING)
Study contacts
- Study coordinator: Dr R Viswa Chandra, MDS;DNB;PhD
- Email: viswachandra@hotmail.com
- Phone: 8179367147
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Intrabony Periodontal Defect