Using hyperpolarized xenon MRI to assess lung function in adults
Official title: Use of Hyperpolarized 129Xe MR Lung Imaging in Adults for Calibration
Run by Children's Hospital Medical Center, Cincinnati · NCT02316379 · Data updated 2026-11-12
This study is testing if a special type of MRI using xenon gas can help us see how well the lungs are working in healthy adults.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Children's Hospital Medical Center, Cincinnati Academic / other |
| Locations | 1 site (Cincinnati, Ohio) |
| Status | Recruiting |
| Started | February 2015 |
| Main results expected | December 24, 2031 |
| Study ends | December 24, 2032 |
| Registry record updated | September 14, 2026 |
| Trial ID | NCT02316379 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy adults aged 18 and older who can hold their breath for up to 16 seconds.
✕Probably not a fit
Patients with a history of heart defects, uncontrolled asthma, or respiratory infections may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of hyperpolarized 129Xe MRI for assessing lung function in healthy adults. Participants will inhale hyperpolarized xenon gas and undergo MRI scans to capture detailed images of lung function. The imaging sessions will occur on a single day, with follow-up assessments scheduled one day and 30 days post-imaging. The goal is to optimize imaging techniques for future applications in respiratory disorders.
Why it matters
Potential benefit: If successful, this approach could enhance the diagnosis and monitoring of respiratory disorders through improved imaging techniques.
How similar studies have gone: While the use of hyperpolarized xenon MRI is a novel approach, similar imaging techniques have shown promise in assessing lung function in other studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults ages 18 years and older * Participant must be able to hold their breath for up to 16 seconds Exclusion Criteria: * History of heart defect * Pregnancy or positive pregnancy test * History of uncontrolled asthma defined for this study as requiring use of rescue inhaler ≥ 2 times in past month. * Symptoms of respiratory infection (loose or productive cough or wheeze), chest tightness, or sinus infection within past week. * Baseline oximetry at MRI visit of less than 95% on room air or less than 95% on a previously prescribed dosage of oxygen delivered by nasal cannula. * Participant is claustrophobic and unable to tolerate the imaging. * Standard MRI exclusions (metal, implants).
Where it's running
-
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States Recruiting
Study contacts
- Principal investigator: Jason C Woods, Ph.D. — Children's Hospital Medical Center, Cincinnati
- Study coordinator: Carrie Stevens, BS
- Email: Carrie.Stevens@cchmc.org
- Phone: 513-636-9973
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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-
Using hyperpolarized xenon gas for lung imaging in children and adults
This study is testing if breathing in a special gas during MRI scans can help doctors see how well the lungs are working in both healthy people and those with breathing problems.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.