Using hyperpolarized xenon gas for lung imaging in children and adults
Use of Hyperpolarized 129 Xe MR Lung Imaging in Children and Adults
This study is testing if breathing in a special gas during MRI scans can help doctors see how well the lungs are working in both healthy people and those with breathing problems.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Enrollment | 300 (estimated) |
| Ages | 6 Years and up |
| Sex | All |
| Sponsor | Children's Hospital Medical Center, Cincinnati Academic / other |
| Locations | 1 site (Cincinnati, Ohio) |
| Trial ID | NCT02272049 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of hyperpolarized 129Xe gas MRI for assessing lung function in both healthy individuals and those with respiratory disorders. Participants will inhale hyperpolarized xenon gas during MRI scans, which will be conducted in a single session at Cincinnati Children's Hospital Medical Center. The study aims to gather data on lung function through a series of imaging sessions, including both hyperpolarized xenon and conventional proton MRI. Follow-up assessments will occur one day and 30 days post-imaging to monitor any changes or effects.
Who should consider this trial
Good fit: Ideal candidates include children and adults aged 6 and older who can hold their breath for up to 16 seconds.
Not a fit: Patients with a history of heart defects, uncontrolled asthma, or those who are claustrophobic may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could provide a non-invasive method for assessing lung function in patients with respiratory disorders.
How similar studies have performed: While the use of hyperpolarized xenon gas for lung imaging is a novel approach, similar imaging techniques have shown promise in other studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Ages 6 and up * Participant must be able to hold breath for up to 16 seconds Exclusion Criteria: * History of heart defect * Pregnancy or positive pregnancy test * History of uncontrolled asthma defined for this study as requiring use of rescue inhaler ≥ 2 times in past month * Symptoms of respiratory infection (loose or productive cough or wheeze), chest tightness, or sinus infection within past week * Baseline oximetry at MRI visit of less than 95% on room air or less than 95% on a previously prescribed dosage of oxygen delivered by nasal cannula * Participant is claustrophobic and unable to tolerate the imaging. * Standard MRI exclusions (metal, implants)
Where this trial is running
Cincinnati, Ohio
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States (Recruiting)
Study contacts
- Principal investigator: Jason C. Woods, PhD — Children's Hospital Medical Center, Cincinnati
- Study coordinator: Carrie Stevens, BS
- Email: Carrie.Stevens@cchmc.org
- Phone: 513-636-9973
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.