Using hyperpolarized xenon gas for lung imaging in children and adults
Official title: Use of Hyperpolarized 129 Xe MR Lung Imaging in Children and Adults
Run by Children's Hospital Medical Center, Cincinnati · NCT02272049 · Data updated 2026-11-12
This study is testing if breathing in a special gas during MRI scans can help doctors see how well the lungs are working in both healthy people and those with breathing problems.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Ages | 6 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Children's Hospital Medical Center, Cincinnati Academic / other |
| Locations | 1 site (Cincinnati, Ohio) |
| Status | Recruiting |
| Started | December 2014 |
| Main results expected | December 31, 2028 |
| Study ends | August 31, 2029 |
| Registry record updated | February 17, 2026 |
| Trial ID | NCT02272049 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include children and adults aged 6 and older who can hold their breath for up to 16 seconds.
✕Probably not a fit
Patients with a history of heart defects, uncontrolled asthma, or those who are claustrophobic may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of hyperpolarized 129Xe gas MRI for assessing lung function in both healthy individuals and those with respiratory disorders. Participants will inhale hyperpolarized xenon gas during MRI scans, which will be conducted in a single session at Cincinnati Children's Hospital Medical Center. The study aims to gather data on lung function through a series of imaging sessions, including both hyperpolarized xenon and conventional proton MRI. Follow-up assessments will occur one day and 30 days post-imaging to monitor any changes or effects.
Why it matters
Potential benefit: If successful, this approach could provide a non-invasive method for assessing lung function in patients with respiratory disorders.
How similar studies have gone: While the use of hyperpolarized xenon gas for lung imaging is a novel approach, similar imaging techniques have shown promise in other studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Ages 6 and up * Participant must be able to hold breath for up to 16 seconds Exclusion Criteria: * History of heart defect * Pregnancy or positive pregnancy test * History of uncontrolled asthma defined for this study as requiring use of rescue inhaler ≥ 2 times in past month * Symptoms of respiratory infection (loose or productive cough or wheeze), chest tightness, or sinus infection within past week * Baseline oximetry at MRI visit of less than 95% on room air or less than 95% on a previously prescribed dosage of oxygen delivered by nasal cannula * Participant is claustrophobic and unable to tolerate the imaging. * Standard MRI exclusions (metal, implants)
Where it's running
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States Recruiting
Study contacts
- Principal investigator: Jason C. Woods, PhD — Children's Hospital Medical Center, Cincinnati
- Study coordinator: Carrie Stevens, BS
- Email: Carrie.Stevens@cchmc.org
- Phone: 513-636-9973
Similar studies
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Using hyperpolarized xenon MRI to assess lung function in adults
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.