Using hyperpolarized 13C MRI to visualize cancer metabolism
Official title: Hyperpolarized 13-C Pyruvate MRI Surveillance of Multiple Cancers
Run by University of Maryland, Baltimore · NCT05697406 · Data updated 2026-11-12
This study is testing a new type of MRI that uses special imaging to see how tumors use energy, helping doctors understand different types of cancer better.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 88 Years |
| Sex | All |
| Enrollment | 25 (estimated) |
| Sponsor | University of Maryland, Baltimore Academic / other |
| Locations | 1 site (Baltimore, Maryland) |
| Status | Recruiting |
| Started | June 24, 2024 |
| Main results expected | December 1, 2026 |
| Study ends | December 1, 2028 |
| Registry record updated | September 22, 2025 |
| Trial ID | NCT05697406 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients with a confirmed diagnosis of cancer who are scheduled for MR imaging.
✕Probably not a fit
Patients without a tumor diagnosis or those unable to undergo MR imaging will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the use of hyperpolarized 13C pyruvate MRI imaging to visualize metabolic processes in tumors, particularly focusing on the Warburg effect, where cancer cells convert pyruvate to lactate. By employing this advanced imaging technique, the study aims to detect and characterize various types of tumors based on their metabolic activity. The research will involve patients with confirmed tumor diagnoses who are scheduled for MR imaging, allowing for a comprehensive analysis of tumor metabolism in real-time. This approach seeks to improve upon traditional imaging methods that only assess early glycolytic activity.
Why it matters
Potential benefit: If successful, this imaging technique could provide a more accurate and detailed understanding of tumor metabolism, leading to better diagnosis and treatment strategies for cancer patients.
How similar studies have gone: While hyperpolarized 13C pyruvate imaging has shown promise in specific cancer models, its application in a broader range of tumors is still being explored, making this approach relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Clinical tumor diagnosis Patients with pre-existing MR imaging appointments Must be able to undergo MR Exclusion Criteria: No tumor diagnosis
Where it's running
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University of Maryland Medical Center
Baltimore, Maryland, United States Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.