Clinical trial No longer in our active list Interventional Ages 19 and up

Using hyperbaric oxygen therapy to treat pain in sickle cell anemia

Official title: Hyperbaric Oxygen Therapy in Sickle Cell Pain

Run by University of Nebraska · NCT03412045 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study is testing if hyperbaric oxygen therapy can help adults with sickle cell anemia feel less pain during a pain crisis and recover faster.

Quick facts

Study typeInterventional
Ages19 Years and up
SexAll
Enrollment10 (estimated)
SponsorUniversity of Nebraska
Academic / other
Locations1 site (Omaha, Nebraska)
Trial IDNCT03412045 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 19 and older who present with an uncomplicated sickle cell crisis.

Probably not a fit

Patients with complicated sickle cell crises or those under 19 years old may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of hyperbaric oxygen (HBO) therapy on patients experiencing an uncomplicated acute pain crisis due to sickle cell anemia. Participants aged 19 and older will receive 1-3 sessions of HBO therapy, each lasting approximately two hours, to assess its impact on pain levels and hospital length of stay. Pain will be evaluated using a visual analog scale before and after treatment. The goal is to determine if HBO therapy can effectively reduce pain and improve recovery times for these patients.

Why it matters

Potential benefit: If successful, this treatment could significantly reduce pain and shorten hospital stays for patients suffering from sickle cell crises.

How similar studies have gone: While some previous studies have suggested benefits of HBO therapy for sickle cell pain, results have been inconsistent and this approach remains largely untested in larger populations.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 19 years old or older
* Present with an uncomplicated sickle cell crisis at admission friom the emergency department

Exclusion Criteria:

* \< 19 years old
* pregnant female
* complicated sickle cell crisis present (i.e., concomitant MI, stroke, acute chest syndrome at time of presentation)

Where it's running

  • Unversity of Nebraska Medical Center
    Omaha, Nebraska, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.