Using hyperbaric oxygen therapy to treat pain in sickle cell anemia
Official title: Hyperbaric Oxygen Therapy in Sickle Cell Pain
Run by University of Nebraska · NCT03412045 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing if hyperbaric oxygen therapy can help adults with sickle cell anemia feel less pain during a pain crisis and recover faster.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 19 Years and up |
| Sex | All |
| Enrollment | 10 (estimated) |
| Sponsor | University of Nebraska Academic / other |
| Locations | 1 site (Omaha, Nebraska) |
| Trial ID | NCT03412045 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 19 and older who present with an uncomplicated sickle cell crisis.
✕Probably not a fit
Patients with complicated sickle cell crises or those under 19 years old may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of hyperbaric oxygen (HBO) therapy on patients experiencing an uncomplicated acute pain crisis due to sickle cell anemia. Participants aged 19 and older will receive 1-3 sessions of HBO therapy, each lasting approximately two hours, to assess its impact on pain levels and hospital length of stay. Pain will be evaluated using a visual analog scale before and after treatment. The goal is to determine if HBO therapy can effectively reduce pain and improve recovery times for these patients.
Why it matters
Potential benefit: If successful, this treatment could significantly reduce pain and shorten hospital stays for patients suffering from sickle cell crises.
How similar studies have gone: While some previous studies have suggested benefits of HBO therapy for sickle cell pain, results have been inconsistent and this approach remains largely untested in larger populations.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 19 years old or older * Present with an uncomplicated sickle cell crisis at admission friom the emergency department Exclusion Criteria: * \< 19 years old * pregnant female * complicated sickle cell crisis present (i.e., concomitant MI, stroke, acute chest syndrome at time of presentation)
Where it's running
-
Unversity of Nebraska Medical Center
Omaha, Nebraska, United States Recruiting
Study contacts
- Principal investigator: Jeff S Cooper, MD — University of Nebraska
- Study coordinator: Jeff S Cooper, MD
- Email: jeffrey.cooper@unmc.edu
- Phone: 402-552-2490
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.