Using Hyperbaric Oxygen Therapy to Heal Hamstring Injuries

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of Hyperbaric Oxygen Therapy (HBOT) in accelerating recovery from acute hamstring injuries. Participants will undergo seven daily sessions of HBOT, and their recovery times will be compared to a historical control group receiving standard care. The study will also assess the healing process through clinical evaluations and MRI imaging, as well as track the occurrence of reinjuries within one year. Key metrics include the time to return to play and various pain and functional assessments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* The participant is male or female, of any ethnic origin
* The participant is between 18 and 65 years old
* The participant has a clinical diagnosis of an acute hamstring injury ≤7 days old, defined as:

  * Anamnestic acute injury
  * Anamnestic pain in the posterior thigh
  * Localized pain during palpation of hamstring muscle
  * Localized pain during passive straight leg raise
  * Increased pain during isometric contraction
* The participant is able to start of HBOT treatment ≤7 days)

Exclusion Criteria:

* The participant is not capable of doing an active exercise program.
* The participant does not have the intention to full sporting activity or duty activities;
* The cause of the hamstring injury is an extrinsic trauma on the posterior thigh;
* The participant has a chronic hamstring injury \>2 months, defined as recurrent pain or tenderness of the hamstring;
* The current injury is a re-injury ≤2months after RTP/RTD after acute ipsilateral hamstring injury;
* Clinical suspicion of a complete proximal tendon avulsions;
* Presence of other concurrent injuries inhibiting rehabilitation;
* The participant is not able to give informed consent;
* There are contra-indications for MRI: Pacemaker, pregnancy and claustrophobia
* There are contra-indications for HBOT:

  * Smoking or quit smoking \<3 months prior to injury;
  * A previous spontaneous pneumothorax.
  * Implantation of ICD or PM not compatible with hyperbaric pressure
  * Current or recent (\<6 months) use of cytostatics
  * Unable to perform a Valsalva manoeuvre to pressurize the middle ear (pre-existent ear-nose-throat complaints or a current upper airway infection).
  * Pregnancy
  * Claustrophobia

Where it's running

• Amsterdam UMC
  Amsterdam, North Holland, Netherlands Recruiting

Study contacts

• Study coordinator: Milo J.K. Mokkenstorm, MD MSc
• Email: m.j.mokkenstorm@amsterdamumc.nl
• Phone: +31 681076920

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.