Using hydrogen peroxide and ultraviolet-C light to disinfect ICU surfaces

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This cluster-randomized, crossover trial will be conducted in 12 Brazilian ICUs, with each unit sequentially implementing three strategies: routine disinfection alone, routine disinfection followed by 7.9% hydrogen peroxide aerosolized inside a protective tent during terminal bed cleaning, and routine disinfection followed by automated ultraviolet-C irradiation applied under the same tent. Units are randomized by cluster and cross over between strategies so outcomes during each period can be compared. The trial links these unit-level disinfection strategies to patient-centered outcomes including ventilator-associated pneumonia, catheter-related bloodstream infections, and urinary tract infections while also monitoring environmental contamination and antimicrobial use. Results will determine whether reductions in surface bioburden translate into fewer ICU-acquired infections.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All patients aged 18 years and older who will be admitted to the participating ICUs

Exclusion Criteria:

* Patients under 18 years
* ICUs that use peroxide hydrogen or ultraviolet light for surface disinfection as part of their protocol

Where it's running

• Hospital Maternidade Sao Vicente De Paulo
  Barbalha, Ceará, Brazil Recruiting
• Instituto Hospital de Base
  Brasília, Federal District, Brazil Recruiting
• Hospital Estadual de Aparecida de Goiânia
  Aparecida de Goiânia, Goiás, Brazil Recruiting
• Santa Casa de Misericórdia de Passos
  Passos, Minas Gerais, Brazil Recruiting
• Fundo Municipal de Saúde de Maringá
  Maringá, Paraná, Brazil Recruiting
• Hospital da Restauração
  Recife, Pernambuco, Brazil Recruiting

Study contacts

• Principal investigator: Antonio P Nassar Jr, PhD — Hospital Israelita Albert Einstein
• Study coordinator: Antonio P Nassar Jr, PhD
• Email: antonio.nassar@einstein.br
• Phone: 551121519617

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.