Using Hyaluronic Acid to Treat Periodontitis
Healing of Periodontal Suprabony Defects Following Treatment With Open Flap Debridement With or Without Hyaluronic Acid (HA) Application
NA · Federico II University · NCT05073575
This study is testing if adding hyaluronic acid during gum surgery helps people with periodontitis heal better compared to surgery alone.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Federico II University (other) |
| Locations | 1 site (Naples) |
| Trial ID | NCT05073575 on ClinicalTrials.gov |
What this trial studies
This investigation aims to evaluate the healing of suprabony defects in patients with periodontitis by comparing two treatment approaches: one involving the application of hyaluronic acid during surgical flap elevation and the other using surgical flap elevation alone. A total of 80 patients will be randomly assigned to either the hyaluronic acid group or the no-hyaluronic acid group. The primary outcome measured will be the Clinical Attachment Level (CAL) gain, while secondary outcomes will include Probing Depth (PD) and Gingival Recession (GR). The study will utilize specific incision techniques based on the width of the interproximal space to access the defect area effectively.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older diagnosed with periodontitis and having specific suprabony periodontal defects.
Not a fit: Patients with systemic diseases, those on prolonged antibiotic or anti-inflammatory treatments, or pregnant or lactating individuals may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could enhance healing outcomes for patients with periodontal bone loss.
How similar studies have performed: Other studies have shown promising results with the use of hyaluronic acid in periodontal treatments, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients diagnosed with periodontitis * Age ≥ 18 years old * Single-rooted and multi-rooted teeth * Presence of suprabony periodontal defects at a minimum of two adjacent teeth and a maximum of 7 adjacent teeth in either the maxilla or the mandible with a PD ≥ 5 mm after completion of non-surgical periodontal treatment and re-evaluation * Intrabony defect with an intraosseous component \< 2 mm Exclusion Criteria: * Patients with systemic diseases * Prolonged antibiotic or anti-inflammatory treatment within 4 weeks prior to surgery * Pregnant or lactating * Tobacco smokers (≥ 10 cigarettes per day) * Multi-rooted teeth with furcation involvement * Increased tooth mobility (grade II and III)
Where this trial is running
Naples
- University of Naples Federico II — Naples, Italy (RECRUITING)
Study contacts
- Study coordinator: Luca Ramaglia
- Email: luca.ramaglia@unina.it
- Phone: +393476912911
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Periodontal Bone Loss, Hyaluronic Acid, Suprabony Defect, Surgical Periodontal Therapy