Using hyaluronic acid gel to prevent adhesions after surgery for retained pregnancy tissue
Official title: The Efficacy of Auto-crosslinked Hyaluronic Acid Gel in the Prevention of Adhesion Reformation After Hysteroscopic Resection of Retained Products of Conception:a Randomized Controlled Trial
Run by Fu Xing Hospital, Capital Medical University · NCT05085067 · Data updated 2026-11-12
This study is testing if a special gel can help prevent complications like infertility after surgery for leftover pregnancy tissue.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 86 (estimated) |
| Sponsor | Fu Xing Hospital, Capital Medical University Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | April 1, 2022 |
| Main results expected | April 30, 2025 |
| Study ends | May 30, 2025 |
| Registry record updated | March 12, 2025 |
| Trial ID | NCT05085067 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women diagnosed with retained products of conception who are undergoing hysteroscopic resection.
✕Probably not a fit
Patients with severe complications from surgery or those with active genital tract infections may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effectiveness of auto-cross linked hyaluronic acid gel in preventing the reformation of intrauterine adhesions following hysteroscopic resection of retained products of conception (RPOC). RPOC can lead to complications such as infertility and menstrual abnormalities if not treated properly. The study will randomly assign patients who have undergone the surgical procedure to receive either the gel or standard care, allowing for a comparison of outcomes related to adhesion formation. The goal is to determine if the gel can reduce the risk of complications associated with RPOC treatment.
Why it matters
Potential benefit: If successful, this treatment could significantly improve fertility outcomes for patients who have experienced retained products of conception.
How similar studies have gone: While the use of hyaluronic acid gel in this context is promising, similar studies have shown mixed results, indicating that this approach may still be novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of retained products of conception * Written consent obtained Exclusion Criteria: * Patients with severe complications of medicine and surgery * Acute or chronic genital tract inflammation * No understanding or approving the randomized controlled trial
Where it's running
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FuxingHospital,Captital Medical University
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Study coordinator: Xue Yang, Master
- Email: yuanxy515@163.com
- Phone: 8618810957056
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Drug-assisted expectant care versus surgery for retained products of conception
This project tests whether trying drug-assisted expectant management and waiting for the right time for surgery in people with retained products of conception reduces intrauterine scarring and better preserves fertility compared with immediate curettage.
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Operative hysteroscopy in the operating room versus the outpatient clinic
This will test whether operative hysteroscopy done in an outpatient clinic works as well as when it's done in the operating room for women treated for fibroids, polyps, or retained products of conception.
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Intracervical vasopressin to help hysteroscopic removal of retained pregnancy tissue.
This test checks whether injecting vasopressin into the cervix during hysteroscopic removal helps women 18–51 have complete removal of retained pregnancy tissue.
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Evaluating conservative management for retained products of conception and enhanced myometrial vascularity
This study is testing if gentle treatments for people with leftover pregnancy tissue after a miscarriage can help them recover naturally over two menstrual cycles.
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Hysteroscopy for treating retained products of conception after miscarriage
This study tests whether a procedure called hysteroscopy helps women who had a miscarriage and still have some pregnancy tissue to get pregnant again faster compared to just waiting it out.
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Misoprostol versus watchful waiting for retained tissue after first-trimester medical abortion
This project will test whether taking misoprostol or simply watching and waiting works better to clear retained tissue after a first‑trimester medical abortion in women aged 18–45 with ultrasound evidence of retained products.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.