Using high flow therapy to improve airway stenting outcomes
Impact of High Flow Therapy Through Nasal Cannula on Complications Related to Airway Stenting: a Prospective, Multicentric, Randomized-controlled Trial
This study is testing if high flow nasal therapy can help people with airway stents breathe better and avoid complications compared to the usual saline treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Cardarelli Hospital Academic / other |
| Locations | 1 site (Napoli) |
| Trial ID | NCT06069817 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of high flow nasal cannula (HFNC) therapy in patients with airway stents to enhance humidification and facilitate the clearance of airway secretions. By comparing HFNC therapy to the standard treatment of nebulized normal saline, the study aims to determine if HFNC can reduce complications such as mucoid impaction and respiratory infections. The intervention targets patients with central airway obstruction who have undergone stenting, focusing on improving their respiratory health and reducing the risk of complications.
Who should consider this trial
Good fit: Ideal candidates include individuals with central airway obstruction, both malignant and nonmalignant, who have received airway stenting.
Not a fit: Patients who have had recent nose surgery or facial trauma, or those with neuropsychiatric disorders or pregnancy, may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce respiratory complications in patients with airway stents.
How similar studies have performed: While the specific application of HFNC in this context is novel, similar studies have shown promising results in improving respiratory outcomes with high flow therapy.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Written informed consent * Central Airway obstruction, both malignant and nonmalignant, treated with airway stenting (silicone or fully covered metallic stent) Exclusion Criteria: * Contraindication to HFNC (recent - within 3 months - nose surgery or facial trauma) * Lack of written informed consent * Neuropsychiatric disorders * Pregnancy
Where this trial is running
Napoli
- Interventional Pulmonology Unit, Cardarelli Hospital — Napoli, Italy (Recruiting)
Study contacts
- Principal investigator: Nadia Corcione, MD, PhD — Ospedale "Antonio Cardarelli", Naples
- Study coordinator: Nadia Corcione, MD, PhD
- Email: nadia.corcione@gmail.com
- Phone: + 39 0817473393
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.