Using high-flow oxygen therapy for migraine relief in the emergency department
Official title: Migraine and High Flow Oxygenotherapy at the Emergency Department
Run by Centre Hospitalier Universitaire de Nice · NCT04925414 · Data updated 2026-11-12
This study is testing if high-flow oxygen therapy can help people in the emergency department feel better during a migraine attack and reduce their time spent in the ER.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Nice Academic / other |
| Locations | 1 site (Nice) |
| Status | Recruiting |
| Started | October 1, 2023 |
| Main results expected | April 2025 |
| Study ends | April 2025 |
| Registry record updated | November 18, 2024 |
| Trial ID | NCT04925414 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who are experiencing a migraine attack and are admitted to the emergency department.
✕Probably not a fit
Patients with chronic respiratory conditions such as COPD or those who have recently used specific migraine medications may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of high-flow oxygen therapy on patients experiencing migraine attacks in the emergency department. It aims to determine whether normobaric oxygen can alleviate migraine symptoms, potentially reducing the need for conventional analgesics and shortening emergency room stays. The study is designed as a multicenter, prospective, single-blind, randomized, placebo-controlled trial, comparing the efficacy of oxygen therapy against a placebo. Participants will be monitored for improvements in their migraine symptoms and overall experience during treatment.
Why it matters
Potential benefit: If successful, this approach could provide a safer and more effective treatment option for migraine sufferers, reducing reliance on traditional pain medications.
How similar studies have gone: While the use of high-flow oxygen therapy has been validated for cluster headaches, its application for migraines is novel and has not been extensively tested in previous studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years old or more * Affiliated to a french public health insurance * ED admission for migraine evocative headache, regarding ICHD3 criterions * written informed consent Exclusion Criteria: * COPD or other chronic respiratory failure conditions * Pregnant or breastfeeding women or women of childbearing potential not using any means of contraception. A pregnancy test will be performed for women of childbearing age. The results will be communicated to the patient by a doctor of her choice. * Under legal protection * Patients who have received treatment with triptan in the past 2 weeks * Patients who have consumed NSAIDs in the hour before the doctor's examination * State of migraine headache (crippling attack for more than 72 hours)
Where it's running
-
CHU de Nice
Nice, France Recruiting
Study contacts
- Study coordinator: Julie CONTENTI
- Email: contenti.j@chu-ice.fr
- Phone: +334.92.03.85.35
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.