Using high-flow nasal cannula to prevent low oxygen levels during intubation in children
Application of HFNC for the Prevention of Hypoxemia During Perioperative Anesthetic-induced Intubation in Children: A Randomized Controlled Clinical Trial
NA · Henan Provincial People's Hospital · NCT06425406
This study is testing if using a high-flow nasal cannula can help prevent low oxygen levels in children aged 2-10 during the process of intubation for surgery.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 48 (estimated) |
| Ages | 2 Years to 10 Years |
| Sex | All |
| Sponsor | Henan Provincial People's Hospital (other) |
| Drugs / interventions | radiation |
| Locations | 1 site (Zhengzhou, Henan) |
| Trial ID | NCT06425406 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness of high-flow nasal cannula (HFNC) in preventing hypoxemia during the critical period of tracheal intubation in children aged 2-10 years. Given that children have unique physiological characteristics that make them more susceptible to low oxygen levels, the study aims to explore how HFNC can improve oxygenation compared to traditional methods. The trial will involve monitoring oxygen levels and respiratory function during anesthesia induction and intubation, utilizing ultrasound for additional assessment of gastric distension. The goal is to establish a safer pre-oxygenation strategy for pediatric patients undergoing surgery.
Who should consider this trial
Good fit: Ideal candidates are children aged 2-10 years with healthy lungs and hearts, classified as ASA Level I or II.
Not a fit: Patients with upper respiratory tract infections, significant pulmonary dysfunction, or those who refuse HFNC may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the risk of hypoxemia and related complications during pediatric intubation.
How similar studies have performed: While there are limited studies specifically on HFNC in children during intubation, its use in adults has shown promising results, indicating potential for success in this pediatric application.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 2-10 years old; * American Society of Anesthesiologists (ASA) Level I or II; * Children with healthy lungs and hearts; * Clear headed and able to cooperate with anesthesiologists for treatment. Exclusion Criteria: * Contraindications for HFNC: (1) Complete obstruction of the upper respiratory tract; (2) Skull base fracture or nasal bone fracture; (3) Patients who refuse to use HFNC; * The American Society of Anesthesiologists (ASA) rating is greater than Level II; * Children with upper respiratory tract infections within 2 weeks; * Pulmonary dysfunction, congenital heart disease in children;
Where this trial is running
Zhengzhou, Henan
- Department of Anaesthesiology and Perioperative Medicine, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital — Zhengzhou, Henan, China (RECRUITING)
Study contacts
- Study coordinator: KuangYu Zhao
- Email: 844523078@qq.com
- Phone: +8613251535857
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: High-flow Nasal Cannula, Children, Pre-oxygenation