Using high-dose gentamicin cement with clindamycin for hip and knee prostheses
Local Antibiotic Prophylaxis With Antibiotic Cement: Interest of High-dose Gentamicin Cement Associated With Clindamycin in Changes of Hip and Knee Prostheses
This study is testing if using high-dose gentamicin cement along with clindamycin can help prevent infections in people who have had hip or knee replacement surgeries.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Strasbourg, France Academic / other |
| Locations | 1 site (Strasbourg) |
| Trial ID | NCT06183606 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the effectiveness of high-dose gentamicin cement combined with clindamycin in patients who have undergone hip or knee replacement surgeries. The orthopedic team at the University Hospital of Strasbourg has been utilizing gentamicin cement for years, as it has shown promising results in improving the survival rates of prostheses. The study aims to optimize local antibiotic prophylaxis to combat infections associated with prosthetic implants, particularly focusing on the challenges posed by biofilm-forming bacteria. Data will be collected from patients operated on between February 2017 and January 2019 who consent to the reuse of their data for this research.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older who had hip or knee replacement surgeries at the University Hospital of Strasbourg during the specified time frame.
Not a fit: Patients who opposed participation in the study will not benefit from the findings.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the risk of infections in patients receiving hip and knee prostheses.
How similar studies have performed: Previous studies have indicated that the use of gentamicin cement can improve prosthesis survival rates, suggesting a potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: * Adult subject (≥18 years old) * Patient operated on at the HUS between 01/02/2017 and 31/01/2019, for replacement of hip and knee prostheses * Patient having given their consent for the reuse of their data for the purposes of this research Exclusion criteria: - Patient who expressed their opposition to participating in the study
Where this trial is running
Strasbourg
- Service de Chirurgie Orthopédique Septique - CHU de Strasbourg - France — Strasbourg, France (Recruiting)
Study contacts
- Study coordinator: Jeannot GAUDIAS, MD
- Email: jeannot.gaudias@chru-strasbourg.fr
- Phone: 33 3 68 76 50 62
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.