Using hemadsorption to remove drugs in intoxicated ICU patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates the effectiveness of a hemadsorption filter (cytosorb®) in enhancing the elimination of benzodiazepines and tricyclic antidepressants in patients admitted to the ICU with impaired consciousness due to drug intoxication. The study involves administering the hemadsorption filter to patients who meet specific criteria, including prolonged impaired consciousness and risk factors for delayed drug elimination. Plasma levels of the neurodepressing drugs will be measured before and after the application of the filter to assess the speed and effectiveness of drug removal.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. older than18 years
2. Admission to ICU
3. GCS \< 8 or requiring Flumazenil 8 hours after hospital admission
4. Having an intoxication with a benzodiazepine or tricyclic antidepressant that we can measure/quantify
5. Having a risk factor for delayed drug elimination defined as either Cirrhosis CHILD B/C or chronic kidney insufficiency KDIGO 3b or worse

Exclusion Criteria:

1. Pregnant patient
2. Patients in chronic dialysis before admission
3. Need for mechanical ventilation for other reasons than intoxications (e.g. pneumonia, neurotrauma)
4. Concomitant pathology requiring continued intravenous sedation
5. Known history of seizures
6. Contra-indication to heparin use
7. DNR restricting the use of mechanical ventilation or dialysis

Where it's running

• Universitair Ziekenhuis Brussel
  Brussels, Brussels Capital, Belgium Recruiting

Study contacts

• Principal investigator: Michaël Mekeirele, Medical Doctor — Universitair Ziekenhuis Brussel
• Study coordinator: Marie-Claire vanmalderen, Study coordinator
• Email: Marieclaire.vanmalderen@uzbrussel.be
• Phone: 0032 24 76 31 10

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.