Using heart rate variability to predict nausea and vomiting after gallbladder surgery
The Predictive Role of Heart Rate Variability in Postoperative Nausea and Vomiting Among Female Patients Undergoing Elective Laparoscopic Cholecystectomy: A Prospective Observational Study
This study is testing if measuring heart rate changes can help predict nausea and vomiting in women after gallbladder surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 110 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | Female |
| Sponsor | Konya City Hospital Academic / other |
| Locations | 1 site (Konya) |
| Trial ID | NCT06948708 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the role of heart rate variability (HRV) as a potential biomarker for predicting postoperative nausea and vomiting (PONV) in female patients undergoing elective laparoscopic cholecystectomy. By measuring HRV before and after surgery, the study aims to determine its predictive value regarding the incidence and severity of PONV. A total of 110 participants will be enrolled, focusing on those who meet specific inclusion criteria, such as being non-smokers and in good physical health. The findings could enhance understanding of PONV risk factors and improve patient management.
Who should consider this trial
Good fit: Ideal candidates are female patients aged 18 to 65 scheduled for elective laparoscopic cholecystectomy who are non-smokers and in good health.
Not a fit: Patients with a history of cardiovascular, neurological, or gastrointestinal diseases, or those on medications affecting HRV may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better prediction and management of postoperative nausea and vomiting, improving patient comfort and recovery.
How similar studies have performed: While the predictive role of HRV in PONV is a novel approach, similar studies have suggested potential benefits, but this specific application remains largely untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female patients aged 18 to 65 years * Scheduled for elective laparoscopic cholecystectomy * American Society of Anesthesiologists (ASA) physical status I-II * Non-smokers * Able and willing to provide written informed consent Exclusion Criteria: * History of cardiovascular, neurological, or gastrointestinal disease * Use of medications affecting HRV (e.g., antihypertensives, diuretics, atropine, antidepressants, antipsychotics, steroids) * Presence of systemic diseases that may affect PONV risk * Inability to comply with study procedures
Where this trial is running
Konya
- Konya City Hospital — Konya, Turkey (Recruiting)
Study contacts
- Study coordinator: Mahmut Tutar, MD
- Email: masatu42@gmail.com
- Phone: +905552723704
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.