Using heart CT imaging to find early coronary artery disease in family members with high or low lipoprotein(a)
Improved Assessment of Cardiovascular Risk Through Imaging in Relatives Identified By Lipoprotein(a) Cascade Screening
This study is testing if heart CT scans can help find early signs of heart disease in family members of people with high or low lipoprotein(a) levels.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 50 Years and up |
| Sex | All |
| Sponsor | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Academic / other |
| Locations | 1 site (Amsterdam, North Holland) |
| Trial ID | NCT06995183 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on individuals who are first-degree relatives of patients with high lipoprotein(a) levels, a cholesterol type linked to increased heart disease risk. Participants undergo cascade screening for lipoprotein(a) and other cardiovascular risk factors at Amsterdam UMC. Those identified with either high or low lipoprotein(a) levels will receive comprehensive cardiovascular evaluations, including blood tests and heart imaging via CT scans to assess early signs of coronary artery disease. The study aims to better understand the relationship between lipoprotein(a) levels and coronary artery health.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 50 and older who are first-degree relatives of patients with high lipoprotein(a) levels.
Not a fit: Patients with renal issues or those not meeting the age and lipoprotein(a) criteria may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to earlier detection and management of coronary artery disease in individuals with high lipoprotein(a).
How similar studies have performed: While studies on lipoprotein(a) and cardiovascular risk exist, this specific approach of family cascade screening and imaging is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
In order to be eligible to participate in this study in the elevated Lp(a) subgroup, a subject must meet all of the following inclusion criteria: * Man or woman ≥50 years of age; * Lp(a) level ≥ 150 nmol/L; * Identified as having elevated Lp(a) through Lp(a) family cascade screening at the Amsterdam UMC Vascular Medicine outpatient clinic; * Able and willing to provide informed consent; * Able to comply with study requirements. In order to be eligible to participate in this study in the Low Lp(a) subgroup, a subject must meet all of the following inclusion criteria: * Man or woman ≥50 years of age; * Lp(a) level \< 50 nmol/L; * Identified as having elevated Lp(a) through Lp(a) family cascade screening at the Amsterdam UMC Vascular Medicine outpatient clinic; * Able and willing to provide informed consent; * Able to comply with study requirements. A potential subject who meets any of the following criteria will be excluded from participation in this study (both subgroups): * Renal insufficiency, defined as eGFR \< 30 ml/min * History of ASCVD (acute coronary syndrome, history of myocardial infarction, stable or unstable angina pectoris or coronary or other arterial revascularization, stroke, transient ischemic attack or peripheral artery disease including aortic aneurysm, all of atherosclerotic origin) * History of atrial fibrillation * Prior and current use of statins * Any other treatment or clinically relevant condition that could interfere with the conduct or interpretation of the study in the opinion of the investigator * Unable or unwilling to provide informed consent * Unable to comply with study requirements.
Where this trial is running
Amsterdam, North Holland
- Amsterdam UMC — Amsterdam, North Holland, Netherlands (Recruiting)
Study contacts
- Study coordinator: Maxim E Annink, MD MSc LLM
- Email: m.e.annink@amsterdamumc.nl
- Phone: +31205669111
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.