Using heart CT imaging to find early coronary artery disease in family members with high or low lipoprotein(a)

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on individuals who are first-degree relatives of patients with high lipoprotein(a) levels, a cholesterol type linked to increased heart disease risk. Participants undergo cascade screening for lipoprotein(a) and other cardiovascular risk factors at Amsterdam UMC. Those identified with either high or low lipoprotein(a) levels will receive comprehensive cardiovascular evaluations, including blood tests and heart imaging via CT scans to assess early signs of coronary artery disease. The study aims to better understand the relationship between lipoprotein(a) levels and coronary artery health.

Why it matters

Who can join: the full rules

In order to be eligible to participate in this study in the elevated Lp(a) subgroup, a subject must meet all of the following inclusion criteria:

* Man or woman ≥50 years of age;
* Lp(a) level ≥ 150 nmol/L;
* Identified as having elevated Lp(a) through Lp(a) family cascade screening at the Amsterdam UMC Vascular Medicine outpatient clinic;
* Able and willing to provide informed consent;
* Able to comply with study requirements.

In order to be eligible to participate in this study in the Low Lp(a) subgroup, a subject must meet all of the following inclusion criteria:

* Man or woman ≥50 years of age;
* Lp(a) level \< 50 nmol/L;
* Identified as having elevated Lp(a) through Lp(a) family cascade screening at the Amsterdam UMC Vascular Medicine outpatient clinic;
* Able and willing to provide informed consent;
* Able to comply with study requirements.

A potential subject who meets any of the following criteria will be excluded from participation in this study (both subgroups):

* Renal insufficiency, defined as eGFR \< 30 ml/min
* History of ASCVD (acute coronary syndrome, history of myocardial infarction, stable or unstable angina pectoris or coronary or other arterial revascularization, stroke, transient ischemic attack or peripheral artery disease including aortic aneurysm, all of atherosclerotic origin)
* History of atrial fibrillation
* Prior and current use of statins
* Any other treatment or clinically relevant condition that could interfere with the conduct or interpretation of the study in the opinion of the investigator
* Unable or unwilling to provide informed consent
* Unable to comply with study requirements.

Where it's running

• Amsterdam UMC
  Amsterdam, North Holland, Netherlands Recruiting

Study contacts

• Study coordinator: Maxim E Annink, MD MSc LLM
• Email: m.e.annink@amsterdamumc.nl
• Phone: +31205669111

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.