Using heart and lung ultrasound plus bedside exams to measure fluid tolerance in ICU patients
Official title: Ultrasound and Clinical Approach for the Dynamic Assessment of Fluid Tolerance in the Intensive Care Unit : FLUID-REACT Study
Run by Centre Hospitalier Universitaire Dijon · NCT06415916 · Data updated 2026-11-12
This project will use cardiac and lung ultrasound together with bedside clinical signs to see if ICU patients needing fluids can safely tolerate additional volume.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Centre Hospitalier Universitaire Dijon Academic / other |
| Locations | 1 site (Dijon) |
| Status | Recruiting |
| Started | March 15, 2024 |
| Main results expected | March 2028 |
| Study ends | March 2028 |
| Registry record updated | February 12, 2026 |
| Trial ID | NCT06415916 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adult ICU patients admitted to CHU Dijon who need intravenous volume expansion and can undergo cardiac and lung ultrasound with informed non-opposition are ideal candidates.
✕Probably not a fit
Patients with poor ultrasound windows, chronic atrial arrhythmias, mechanical cardiac assist devices, or those who are pregnant or under legal protection are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study enrolls adult ICU patients who require volume expansion and records serial cardiac and lung ultrasound alongside clinical signs of congestion. Operators will use ultrasound scores (for example VExUS and lung ultrasound findings) and bedside measures such as capillary refill time and oedema to characterize dynamic fluid tolerance. Patients with poor echogenicity, chronic atrial arrhythmia, or mechanical cardiac support are excluded, and participation is limited to those treated at the enrolling center. Data will be used to link ultrasound and clinical profiles with subsequent tolerance or intolerance of additional intravenous fluids.
Why it matters
Potential benefit: If successful, the approach could help clinicians tailor fluid therapy to avoid fluid overload and reduce organ dysfunction related to venous congestion.
How similar studies have gone: Previous work using lung ultrasound and venous congestion scores has shown promising signals for guiding fluid decisions, but definitive, widely adopted protocols are still lacking.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patient * Patient who has provided non-opposition (or health proxy or a close relative if unable to receive the information) * Patient admitted to intensive care and requiring volume expander Exclusion Criteria: * Person subject to a legal protection measure (curatorship, guardianship) * Person subject to a legal protection measure * Pregnant, parturient or breast-feeding women * Poor echogenicity assessed by the operator * Chronic AC/FA * Mechanical cardiac assistance
Where it's running
-
Chu Dijon Bourgogne
Dijon, France Recruiting
Study contacts
- Study coordinator: Pierre-Grégoire GUINOT
- Email: pierregregoire.guinot@chu-dijon.fr
- Phone: 0380281554
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.