Using GnRH agonist for IVF and FET to improve live birth rates

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare the effectiveness of a dual trigger approach using GnRH agonist versus traditional hCG trigger in women undergoing in vitro fertilization (IVF). Additionally, it evaluates the efficacy of GnRH agonist for luteal phase support compared to a placebo in women undergoing frozen embryo transfer (FET). The study involves a randomized, double-blinded, and placebo-controlled design, ensuring rigorous assessment of outcomes. Participants will be monitored throughout the IVF process, including ovarian stimulation and embryo culture, to determine the impact on live birth rates.

Why it matters

Who can join: the full rules

IVF

Inclusion criteria:

\- Women aged \<43 years at the time of IVF treatment

Exclusion criteria:

* Preimplantation genetic diagnosis treatment
* Use of donor oocytes or donor embryos
* Hydrosalpinx shown on pelvic scanning and not surgically treated
* Women at risk of OHSS

FET

Inclusion criteria:

* Women aged \<43 years at the time of IVF treatment
* Replacing early cleavage embryos or blastocysts after thawing
* FET in natural cycles

Exclusion criteria:

* Frozen early cleavage embryos thawed and cultured to blastocysts prior to transfer as requested by the patient
* Preimplantation genetic diagnosis treatment
* Use of donor oocytes or donor embryos
* Hydrosalpinx shown on pelvic scanning and not surgically treated

Where it's running

• Department of Obstetrics and Gynaecology
  Hong Kong, Hong Kong, China Recruiting

Study contacts

• Principal investigator: Ernest HY Ng, MD — The University of Hong Kong
• Study coordinator: Ernest HY Ng, MD
• Email: nghye@hku.hk
• Phone: 852-28553400

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.