Using Glycyrrhizin to treat infected root canals
Clinical Investigation of the Effectiveness of Glycyrrhizin as Intracanal Medication in Root Canal Disinfection and Inflammatory Cytokines
This study tests if Glycyrrhizin can work better than traditional treatments to clean infected root canals in patients with dental infections.
Quick facts
| Phase | Phase2; Phase3 |
|---|---|
| Study type | Interventional |
| Enrollment | 36 (estimated) |
| Ages | 20 Years to 60 Years |
| Sex | All |
| Sponsor | Mansoura University Academic / other |
| Locations | 1 site (Al Mansurah) |
| Trial ID | NCT06453304 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of Glycyrrhizin as an intracanal medication compared to traditional treatments like calcium hydroxide and Ledermix for disinfecting root canals in patients with apical periodontitis. It focuses on measuring the levels of bacteria and inflammatory cytokines in the root canals and surrounding tissues. The study aims to provide insights into how Glycyrrhizin can influence the inflammatory response associated with dental infections.
Who should consider this trial
Good fit: Ideal candidates are individuals with single-rooted teeth suffering from pulp necrosis and apical periodontitis.
Not a fit: Patients currently on antibiotic treatment, those with systemic diseases, or teeth that cannot be isolated with a rubber dam will not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could offer a more effective option for managing infections in root canals, potentially leading to better patient outcomes.
How similar studies have performed: While the use of Glycyrrhizin in this context is novel, similar studies have shown promise in utilizing alternative intracanal medications for dental infections.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Single-rooted with pulp necrosis and apical periodontitis. Exclusion Criteria: * Receiving antibiotic treatment within the preceding 3 months. * Reporting systemic disease. * Teeth that could not be isolated with rubber dam. * Teeth with periodontal pockets deeper than 3 mm.
Where this trial is running
Al Mansurah
- Alaa Reda Mohamed Eltantawi — Al Mansurah, Egypt (Recruiting)
Study contacts
- Study coordinator: Alaa Eltantawi, phD
- Email: alaa_reda@mans.edu.eg
- Phone: 00201062885600
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.