Using Glycopyrrolate to Improve Lung Function During Surgery
Effect of Perioperative Use of Glycopyrrolate on Lung Function in Patients Under General Anesthesia
NA · Yangzhou University · NCT05693246
This study is testing if glycopyrrolate can help older patients breathe better during and after laparoscopic surgery for stomach tumors.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 65 Years to 80 Years |
| Sex | All |
| Sponsor | Yangzhou University (other) |
| Locations | 1 site (Yangzhou, Jiangsu) |
| Trial ID | NCT05693246 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of glycopyrrolate on lung function in elderly patients undergoing elective laparoscopic surgery for gastrointestinal tumors under general anesthesia. The study aims to determine if glycopyrrolate can help maintain lung compliance and reduce postoperative complications by selectively targeting specific receptors in the autonomic nervous system. Participants will receive either glycopyrrolate or normal saline as a control during the perioperative period. The focus is on understanding how this medication can stabilize heart rate and potentially improve respiratory outcomes during and after surgery.
Who should consider this trial
Good fit: Ideal candidates are elderly patients with ASA Grade I-III who are scheduled for elective laparoscopic radical surgery for gastrointestinal malignant tumors.
Not a fit: Patients with hypersensitivity to glycopyrrolate, significant hepatic or renal insufficiency, or other specified exclusions may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved lung function and reduced complications for elderly patients undergoing surgery.
How similar studies have performed: While the specific use of glycopyrrolate in this context may be novel, similar studies have shown that optimizing perioperative care can significantly improve patient outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Elderly patients undergoing elective laparoscopic radical surgery for gastrointestinal malignant tumors; 2. ASA Grade I-III; 3. BMI 18 to 30 kg /㎡； 4. Operation time≥2 hours. Exclusion Criteria: 1. Hypersensitivity to glycopyrrolate； 2. Clinical diagnosis of hepatic and renal insufficiency； 3. Complicated myasthenia gravis； 4. Prolonged QT interval and other abnormal electrocardiogram； 5. History of mechanical ventilation within six months before surgery； 6. Combined with glaucoma； 7. The patient refused.
Where this trial is running
Yangzhou, Jiangsu
- the Affiliated Hospital of Yangzhou University, Yangzhou University — Yangzhou, Jiangsu, China (RECRUITING)
Study contacts
- Study coordinator: zhuan zhang, professor
- Email: zhangzhuancg@163.com
- Phone: +8615062791355
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Glycopyrrolate, Perioperative period, Lung compliance, Autonomic nervous system