Using genetic testing to improve medication safety for children
Official title: Integrating Pediatric Pharmacogenomic Testing Into the Canadian Health Care System
Run by University of British Columbia · NCT04249375 · Data updated 2026-11-12
This study is testing whether genetic testing can help doctors choose safer medications for children to reduce the risk of bad reactions.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | University of British Columbia Academic / other |
| Locations | 2 sites (Vancouver, British Columbia and 1 other locations) |
| Status | Recruiting |
| Started | February 20, 2020 |
| Main results expected | March 2028 |
| Study ends | March 2028 |
| Registry record updated | May 1, 2026 |
| Trial ID | NCT04249375 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include children whose physicians are considering or currently prescribing medications that are part of the pharmacogenomic testing panels.
✕Probably not a fit
Patients who do not speak or understand English may not benefit from this study due to communication barriers.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project focuses on reducing adverse drug reactions in children by implementing a pharmacogenomic testing program. It aims to evaluate the safety and effectiveness of commonly prescribed medications, including antibiotics, analgesics, and mental health drugs. The study will involve collecting patient information from physicians and developing reports to communicate test results to healthcare providers and families. Additionally, it will assess how these tests and results are understood and utilized by all stakeholders involved.
Why it matters
Potential benefit: If successful, this approach could significantly enhance medication safety and effectiveness for pediatric patients.
How similar studies have gone: Other studies have shown promise in using pharmacogenomic testing to improve medication outcomes, indicating that this approach is both relevant and potentially impactful.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants will be enrolled if they can benefit from pharmacogenomic testing. This means their physician is considering the use of a drug that is part of the panels (analgesics, antibiotics, and mental health medication) or they are already using one. Exclusion Criteria: * Patients who do not speak or understand English.
Where it's running
-
Children's and Women's Health Centre of British Columbia
Vancouver, British Columbia, Canada Recruiting -
Children's Hospital of Eastern Ontario
Ottawa, Ontario, Canada Recruiting
Study contacts
- Study coordinator: Bruce Carleton, PharmD.
- Email: bcarleton@popi.ubc.ca
- Phone: 604-875-2179
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Genetic-guided psychotropic medication choices for adults in Manitoba
This project will test whether using a patient's genetics to guide psychotropic medication choices helps adults in Manitoba who are starting or changing psychiatric medicines.
-
Evaluating drug reactions in patients taking multiple medications using genome sequencing
This study is testing if using genetic information can help doctors better manage medications and reduce bad reactions in patients taking five or more drugs.
-
Registry for understanding how genes affect medication responses
This study is trying to see how your genes affect how you respond to medications, so doctors can better choose the right treatments for you, especially if you're taking several drugs or have had bad reactions to them.
-
Identifying genetic factors in drug reactions in children and adults
This study is trying to find out if genetic differences in children and adults can help explain why some people have bad reactions to medications while others do not.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.