Using genetic testing to guide opioid prescriptions for hernia surgery patients
Feasibility and Efficacy of CYP2D6 Genotype-guided Management of Opioid Analgesics in Patients Undergoing Elective Ventral Hernia Repairs: A Pilot Pragmatic Trial
This study tests if using genetic testing to guide opioid prescriptions can help patients recovering from hernia surgery manage their pain better than the usual methods.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | University of Florida Academic / other |
| Locations | 1 site (Jacksonville, Florida) |
| Trial ID | NCT06565546 on ClinicalTrials.gov |
What this trial studies
This pilot trial evaluates the feasibility of prescribing opioids based on CYP2D6 genotype testing for patients undergoing elective ventral hernia repairs. It compares this genotype-guided approach to standard care in terms of pain management and quality of life outcomes. The study aims to assess the effectiveness of personalized opioid prescribing alongside standard postoperative pain medications like acetaminophen and gabapentin.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old who are scheduled for elective ventral hernia repairs larger than 1.5 cm.
Not a fit: Patients with smaller hernias, those undergoing emergency procedures, or individuals with chronic opioid therapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more effective pain management and improved quality of life for patients after hernia surgery.
How similar studies have performed: While this approach is innovative, similar studies have shown promise in personalized medicine, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * \> 18 years age undergoing a ventral hernia repair (VHR) ≥1.5 cm in diameter with mesh. Exclusion Criteria: * ventral hernia \<1.5 cm * primary ventral hernia repair (VHR) without a mesh * emergency operative procedure * receiving chronic opioid therapy (defined as use of opioids on most days for \>3 months) * allergy to opioids * women of childbearing potential who have a positive pregnancy result as part of their standard pre-surgical workup
Where this trial is running
Jacksonville, Florida
- University of Florida Jacksonville — Jacksonville, Florida, United States (Recruiting)
Study contacts
- Principal investigator: Jana Sacco, MD — Assistant Professor
- Study coordinator: Jennifer Mull, RN
- Email: Jennifer.Mull@jax.ufl.edu
- Phone: 904-244-7988
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.