Using galactooligosaccharides to manage high uric acid levels
The Effectiveness of Galactooligosaccharide on the Treatment of Hyperuricemia
This study tests whether a type of fiber called galactooligosaccharides can help people with high uric acid levels feel better by improving gut health.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 70 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Sun Yat-sen University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Trial ID | NCT06630377 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of galactooligosaccharides (GOS) on hyperuricemia, a condition linked to various chronic diseases. The study aims to explore how GOS may influence gut microbiota and its potential protective mechanisms against elevated uric acid levels. Participants will receive either GOS or a placebo, and their responses will be monitored to assess the efficacy of this intervention. The trial seeks to fill gaps in understanding the relationship between gut health and hyperuricemia.
Who should consider this trial
Good fit: Ideal candidates are local residents aged 18-80 with stable weight and elevated fasting uric acid levels who are not currently on uric acid-lowering medications.
Not a fit: Patients with acute illnesses, chronic inflammatory diseases, or those on interfering diets or medications will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a novel dietary intervention for managing hyperuricemia and reducing the risk of associated chronic diseases.
How similar studies have performed: While animal studies and pilot human trials have shown promise with prebiotics for hyperuricemia, the specific use of galactooligosaccharides in this context remains largely unexplored.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Local residents aged between 18-80 years old; * Stable weight (\<5% weight change over the past 3 months); * Fasting uric acid \> 420 umol/L for male and \> 360 umol/L for female on two different days; * Not taking uric acid lowering drugs or have stopped taking uric acid lowering drugs for over 4 weeks at the time of recruitment; * Absence of any diet or medication that might interfere with uric acid metabolism or gut microbiota, especially antibiotics, prebiotics or probiotics at the least 4 weeks before recruitment Exclusion Criteria: * Acute illness or evidence of any acute or chronic inflammatory of infective diseases; * Participation in regular diet program more than 2 times per week in the latest 3 months prior to recruitment; * Mental illness rendering them unable to understand the nature, scope, and possible consequences of the study; * Women of childbearing age who are pregnant, breast-feeding or preparing for pregnancy; patients who had surgey within the past 6 months or planned surgery during the trial period.
Where this trial is running
Guangzhou, Guangdong
- Sun Yat-Sen University — Guangzhou, Guangdong, China (Recruiting)
Study contacts
- Principal investigator: Min Xia, PhD — Sun Yat-sen University
- Study coordinator: Yan Liu, PhD
- Email: liuyan215@mail.sysu.edu.cn
- Phone: +86-20-87331937
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.