Using fundus imaging to identify coronary microvascular disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the relationship between changes in fundus microcirculation and coronary microvascular dysfunction (CMD) using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). By employing the coronary angiography-derived index of microvascular resistance (caIMR), the study will assess patients who have undergone coronary angiography with no significant coronary artery stenosis. The goal is to evaluate the feasibility of non-invasive identification of CMD through advanced imaging techniques, potentially providing a new diagnostic approach for this condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients who underwent coronary angiography in the Department of Cardiology, Peking University First Hospital;
2. Complete baseline clinical information;
3. Subject who have coronary angiography results, which shows coronary stenosis \< 50%;
4. Older than 18 years;
5. Subjects who have signed informed consent.

Exclusion Criteria:

1. Present serious fundus disease
2. Severe cataract and other ophthalmic diseases, which affect imaging quality;
3. Target coronary vessels provide collateral circulation for chronic complete occlusive lesions;
4. The target coronary angiography agent is poorly filled, overlapped, or severely distorted, and cannot fully expose the location of the lesion;
5. Coronary angiography images are of poor quality and cannot be identified;
6. Active bleeding state;
7. Severe renal insufficiency, contrast agent allergy, and unable to perform coronary angiography.

Where it's running

• Peking university first hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Bo Zheng, Dr — Peking University First Hospital
• Study coordinator: Bo Zheng, Dr
• Email: zhengbopatrick@163.com
• Phone: 13426046980

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Qishenyiqi Dripping Pill for treating Coronary Microvascular Disease

  This study is testing if Qishenyiqi dripping pills can help people with microvascular angina feel better and improve their heart health compared to a placebo.

  Recruiting at 2 sites Phase 4 Qilu Hospital of Shandong University · Jinan, Shandong and 2 other locations · NCT06699420

• Observing coronary microvascular disease in patients

  This study looks at patients with coronary microvascular disease to see how the condition develops and affects their quality of life and heart health.

  Recruiting Henan Institute of Cardiovascular Epidemiology · Zhengzhou · NCT06676137

• Improving heart blood flow and angina in women using an SGLT2 pill (STRONG)

  This trial will test whether taking the SGLT2 pill Brezavvy for 12 weeks can improve coronary microvascular blood flow and reduce angina symptoms in women with non-obstructive coronary artery disease.

  Recruiting Phase 1 University of Virginia · Charlottesville, Virginia · NCT06600178

• Exercise training for patients with chest pain and no blocked arteries

  This study tests if regular aerobic exercise can help people with chest pain but no blocked arteries feel better by improving blood flow in their heart and other organs.

  Recruiting Bispebjerg Hospital · Copenhagen and 1 other locations · NCT06529848

• Registry collecting data on microvascular dysfunction and coronary spasm

  This study is collecting information from patients with microvascular dysfunction and coronary spasm to better understand their experiences and improve their care.

  Recruiting Johannes Gutenberg University Mainz · Mainz, Rhineland-Palatinate · NCT06125392

• Understanding how heart conditions affect tolerance to rapid heart rates

  This study is testing how well people with heart conditions, especially those with coronary artery disease, can handle fast heart rates and whether treating their condition with stents can help them tolerate it better.

  Recruiting Imperial College London · London · NCT05841199

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.