Using fundus imaging to identify coronary microvascular disease
A Clinical Study of Fundus Optical Coherence Tomography Angiography for the Identification of Coronary Microvascular Diseases
Peking University First Hospital · NCT05743140
This study is testing if special eye imaging can help find heart problems related to small blood vessels in people who have normal coronary arteries.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 400 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Peking University First Hospital (other) |
| Drugs / interventions | radiation |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT05743140 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between changes in fundus microcirculation and coronary microvascular dysfunction (CMD) using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). By employing the coronary angiography-derived index of microvascular resistance (caIMR), the study will assess patients who have undergone coronary angiography with no significant coronary artery stenosis. The goal is to evaluate the feasibility of non-invasive identification of CMD through advanced imaging techniques, potentially providing a new diagnostic approach for this condition.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 who have undergone coronary angiography showing less than 50% stenosis and have complete baseline clinical information.
Not a fit: Patients with serious fundus diseases, severe cataracts, or other conditions affecting imaging quality may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to a non-invasive method for early detection of coronary microvascular disease, improving patient outcomes.
How similar studies have performed: Previous studies have indicated a strong association between fundus vascular changes and cardiovascular events, suggesting potential success for this novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients who underwent coronary angiography in the Department of Cardiology, Peking University First Hospital; 2. Complete baseline clinical information; 3. Subject who have coronary angiography results, which shows coronary stenosis \< 50%; 4. Older than 18 years; 5. Subjects who have signed informed consent. Exclusion Criteria: 1. Present serious fundus disease 2. Severe cataract and other ophthalmic diseases, which affect imaging quality; 3. Target coronary vessels provide collateral circulation for chronic complete occlusive lesions; 4. The target coronary angiography agent is poorly filled, overlapped, or severely distorted, and cannot fully expose the location of the lesion; 5. Coronary angiography images are of poor quality and cannot be identified; 6. Active bleeding state; 7. Severe renal insufficiency, contrast agent allergy, and unable to perform coronary angiography.
Where this trial is running
Beijing, Beijing Municipality
- Peking university first hospital — Beijing, Beijing Municipality, China (RECRUITING)
Study contacts
- Principal investigator: Bo Zheng, Dr — Peking University First Hospital
- Study coordinator: Bo Zheng, Dr
- Email: zhengbopatrick@163.com
- Phone: 13426046980
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Coronary Microvascular Disease, coronary microvascular disease, CaIMR, OCT, OCTA, Fundus microcirculation