Using functional MRI to assess recovery in patients with optic neuritis
RESting-state Functional MRI in Patients With Optic Neuritis for ANticipation of reCovEry
Fondation Ophtalmologique Adolphe de Rothschild · NCT04448938
This study is testing if a special brain scan can help doctors understand how well patients with optic neuritis are recovering.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Fondation Ophtalmologique Adolphe de Rothschild (network) |
| Locations | 1 site (Paris, PARIS) |
| Trial ID | NCT04448938 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the brain's resting-state functional MRI (fMRI) in patients diagnosed with optic neuritis. Participants will undergo a multi-parametric MRI, including an additional resting-state fMRI sequence before receiving a gadolinium contrast agent. Alongside the MRI, patients will have a consultation with an ophthalmologist, which includes visual acuity tests and optical coherence tomography. The study seeks to gather data that may help anticipate recovery outcomes for these patients.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old with a clinical suspicion of optic neuritis who require an MRI for diagnosis.
Not a fit: Patients with contraindications to MRI, such as pregnant or breastfeeding women, or those with pre-existing vision impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of recovery patterns in optic neuritis, potentially leading to improved patient management.
How similar studies have performed: While the use of fMRI in assessing neurological conditions is established, this specific application in optic neuritis is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients over 18 years of age * Clinical suspicion of optic neuritis * Benefiting from an MRI for exploration of optic neuritis * Affiliate or beneficiary of a social security scheme * Having received informed information about the study and having given their express consent to participate in the study Exclusion Criteria: * Contraindication to absolute or relative MRI (in particular, pregnant or breastfeeding women) * History of amblyopia * Any pre-existing pathology leading to a decrease in vision (e.g. retinitis pigmentosa, AMD, etc.) * Patient benefiting from a legal protection measure
Where this trial is running
Paris, PARIS
- Fondation A De Rothschild — Paris, PARIS, France (RECRUITING)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Neuritis