Using fresh frozen plasma to treat organophosphate poisoning
Evaluation of Effectiveness of Fresh Frozen Plasma Transfusion as a Novel Adjuvant Treatment in Acute Organophosphate Poisoned Patients. A Randomized Clinical Trial in Poison Control Center Ain Shams University Hospital.
This study is testing if giving fresh frozen plasma can help people with moderate to severe organophosphate poisoning recover better than standard treatments.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 92 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06256796 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the effectiveness of fresh frozen plasma (FFP) transfusion as a treatment for patients suffering from moderate to severe organophosphate poisoning. Conducted at Ain Shams University Hospital in Egypt, the study will randomly assign participants to receive either traditional treatment protocols or FFP. The severity of poisoning will be assessed using the Peradeniya Organophosphorus Poisoning scale, and the outcomes will be compared to determine the potential benefits of FFP in improving patient prognosis.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 60 who have been diagnosed with moderate to severe organophosphate poisoning.
Not a fit: Patients with pre-existing health conditions such as diabetes, cardiac, respiratory, renal, or hepatic diseases, as well as pregnant women, will not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could provide a novel and effective option for improving outcomes in patients with organophosphate poisoning.
How similar studies have performed: While the use of fresh frozen plasma in this context is novel, other studies have explored alternative treatments for organophosphate poisoning with varying degrees of success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: -moderate and severe degree of organophosphate poisoning will be included in this study. Exclusion Criteria: * patients below 18 years or above 60 years. * Patients with history of diabetes, cardiac disease, respiratory, renal disease and hepatic disease. * Pregnant female * Patients suspected of having mixed or unknown exposure * Patients with coagulation disorders. * Patients with hyper sensitivity to FFP or plasma derived products, as these cases are contraindicated to take fresh frozen plasma
Where this trial is running
Cairo
- faculty of medicine Ain Shams University — Cairo, Egypt (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.