Using Fosaprepitant to Treat Nausea and Vomiting

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness and safety of fosaprepitant, a new antiemetic, compared to the standard treatment with ondansetron for patients experiencing nausea and vomiting. The study is designed as a randomized, double-blind trial, meaning neither the participants nor the researchers know who receives which treatment to ensure unbiased results. Fosaprepitant works by blocking neurokinin-1 (NK-1) receptors in the central nervous system, potentially offering a more effective solution for patients who often seek care in emergency departments. The trial will assess how well fosaprepitant alleviates symptoms and its side effects compared to traditional antiemetics.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults at least 18 years old
* Present to an emergency department (ED) for nausea and/or vomiting as defined by the International Classification of Diseases (ICD-10), or identified by treating clinician
* Following the approval of a protocol amendment, study patients who have received an antiemetic and remain persistently nauseated after 2 hours will be eligible to participate in the study

Exclusion Criteria:

* Pregnancy, desiring pregnancy, or lactating
* Antiemetic medication use less than 2 hours prior to screening
* Bradycardia (heart rate less than 60 bpm heart rate)
* Prolonged QTc (\>480ms)
* Not conversant in English or Spanish
* Altered mental status
* Dementia
* Lack of phone for follow-up communication

Where it's running

• Montefiore Medical Center (Montefiore and Weiler EDs)
  The Bronx, New York, United States Recruiting

Study contacts

• Principal investigator: Benjamin W Friedman, MD MS — Montefiore Medical Center
• Study coordinator: Mustfa K Manzur, MD MPH MS
• Email: mmanzur@montefiore.org
• Phone: 718-920-6626

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Using Enterra Therapy to Treat Chronic Nausea and Vomiting

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  Recruiting at 22 sites Enterra Medical, Inc. · Scottsdale, Arizona and 21 other locations · NCT06464926

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.