Using Fluoroethyltyrosine to detect brain tumors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the effectiveness of Fluoroethyltyrosine (FET) Positron Emission Tomography (PET) scans in identifying and characterizing intracranial neoplasms, particularly in differentiating between benign treatment-related changes and tumor recurrence. The study focuses on two populations: those with suspected recurrent high-grade gliomas and metastatic disease, and those prior to primary treatment. Participants will receive a single FET PET scan, with the possibility of up to two repeat scans, to assess the relationship between imaging results and clinical outcomes. Adverse events will be monitored throughout the study.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Presence or suspicion of intracranial neoplasm in two populations:

  * Population 1: Participants after primary treatment (radiation therapy and/or surgery) with suspicion of recurrence on MRI.
  * Three sub-populations will be considered:

    * Recurrent metastatic lesions.
    * Recurrent high-grade gliomas (Grades 3 and 4).
    * Recurrent low-grade gliomas (Grade 2).
  * Population 2: Participants prior to primary treatment with planned biopsy or surgical resection.
* Age \> 3 years.

Participants in other clinical trials will be eligible for this study including patients undergoing surgery guided by 5-aminolevulinic acid.

Exclusion Criteria:

* Participants with known incompatibility to PET or Computerized tomography (CT)/magnetic resonance imaging (MRI) scans.
* Participants unlikely to comply with study procedures, restrictions and requirements and judged by the Investigator to be unsuitable for study participation.

  * Sedation or anesthesia can be used for participants who cannot tolerate the exam.

Where it's running

• University of California, San Francisco
  San Francisco, California, United States Recruiting

Study contacts

• Principal investigator: Michael Thomas, MD — University of California, San Francisco
• Study coordinator: Louise Magat
• Email: Louise.Magat@ucsf.edu
• Phone: (415) 502-1822

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.