Using fluorescence to improve parathyroid identification during surgery
Does Fluorescence With or Without Indocyanine Green Improve Parathyroid Identification and Preservation
This study is testing if using special fluorescence imaging during thyroid and parathyroid surgeries can help doctors find and protect the parathyroid glands better than the usual methods.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 417 (estimated) |
| Ages | 19 Years and up |
| Sex | All |
| Sponsor | University of Alabama at Birmingham Academic / other |
| Locations | 1 site (Birmingham, Alabama) |
| Trial ID | NCT06169735 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate whether fluorescence imaging, with or without the use of indocyanine green dye, can enhance the identification and preservation of parathyroid glands during thyroid and parathyroid surgeries. Accurate identification is critical to prevent complications such as postoperative hypocalcemia and to ensure successful removal of parathyroid adenomas. The study will compare the effectiveness of this new imaging technique against traditional methods currently used in surgical practice. By assessing the outcomes, the research seeks to standardize the use of fluorescence technology in surgical settings.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old undergoing thyroid or parathyroid surgery.
Not a fit: Patients with allergies to iodine, shellfish, or indocyanine green, as well as pregnant individuals, may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to safer surgeries with fewer complications and improved patient outcomes.
How similar studies have performed: Previous studies have shown promise in using fluorescence for parathyroid identification, but this specific approach is still being explored for its clinical utility.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * age greater than 18 years old Exclusion Criteria: * Patients with iodine or shellfish allergies would be excluded. * Patients with allergy to indocyanine green. * Pregnancy
Where this trial is running
Birmingham, Alabama
- UAB Callahan Eye — Birmingham, Alabama, United States (Recruiting)
Study contacts
- Principal investigator: Herbert Chen, MD — University of Alabama at Birmingham
- Study coordinator: Niranjna Swaminathan, MD
- Email: nswaminathan@uabmc.edu
- Phone: 2059297195
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.