Using fingertip CRP point-of-care tests to spot leaks after elective colorectal surgery
Official title: CRP Point-of-care Testing Trajectory, a Predictive Factor for Anastomotic Leak in Elective Colorectal Surgery? A Key to Early Rehabilitation?
Run by Centre Hospitalier Universitaire, Amiens · NCT07464600 · Data updated 2026-11-12
This project will see if daily fingertip CRP point-of-care tests can detect anastomotic leaks early in people having elective colorectal surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Centre Hospitalier Universitaire, Amiens Academic / other |
| Locations | 1 site (Amiens) |
| Status | Recruiting |
| Started | September 17, 2025 |
| Main results expected | November 2028 |
| Study ends | February 2029 |
| Registry record updated | March 11, 2026 |
| Trial ID | NCT07464600 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults undergoing elective colorectal surgery with an anastomosis (open, laparoscopic, or robotic), who can consent and attend postoperative fingertip sampling, are ideal candidates.
✕Probably not a fit
Patients without an anastomosis, those having urgent or emergency surgery, minors, pregnant or breastfeeding people, and those unable to consent are unlikely to benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional protocol tracks postoperative CRP measured by fingertip point-of-care testing from day 1 to day 5 after elective colorectal surgery and compares the day-to-day CRP trajectory with clinical outcomes. Participants will have small blood samples taken from a fingertip for rapid CRP measurement and will undergo abdomino-pelvic CT scanning if clinically indicated. The main aim is to determine whether the POCT CRP trajectory predicts anastomotic leak earlier than standard clinical signs, potentially reducing delay to diagnosis. Patients without an anastomosis, emergency cases, minors, pregnant or breastfeeding people, and those under guardianship are excluded.
Why it matters
Potential benefit: If successful, fingertip CRP point-of-care monitoring could enable earlier detection of anastomotic leaks, which may reduce complications and shorten hospital recovery.
How similar studies have gone: Previous research shows that postoperative CRP levels and their day-to-day changes correlate with anastomotic leak risk, and CRP point-of-care testing is established in other fields, but applying fingertip POCT specifically for early postoperative leak detection is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing elective (non-emergency) colorectal surgery, regardless of the approach (laparotomy, laparoscopy, robotic) and whether there is a protective ileostomy. Exclusion Criteria: * No anastomosis * Urgent surgery * Pregnancy or breast-feeding * Patients under guardianship or trusteeship * Minor patients
Where it's running
-
Amiens University Hospital
Amiens, France Recruiting
Study contacts
- Study coordinator: Jean-Marc Regimbeau, Pr
- Email: Regimbeau.jean-marc@chu-amiens.fr
- Phone: 33+322 088 897
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.