Using fetal MRI to predict complications in pregnancies at risk of preterm birth
Individualised Risk Prediction of Adverse Neonatal Outcome in Pregnancies That Deliver Preterm Using Advanced MRI Techniques and Machine Learning
This study is testing if fetal MRI can help doctors spot problems in babies' brains and lungs during pregnancies at risk of preterm birth to improve their health outcomes.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 175 (estimated) |
| Ages | 16 Years and up |
| Sex | Female |
| Sponsor | King's College London Academic / other |
| Locations | 1 site (London, Greater London) |
| Trial ID | NCT05164432 on ClinicalTrials.gov |
What this trial studies
This study aims to utilize fetal Magnetic Resonance Imaging (MRI) to assess the development of the baby's brain and lungs, as well as to evaluate the placenta and thymus for signs of infection in pregnancies at risk of preterm birth. By identifying subtle infections and abnormal development, the researchers hope to improve outcomes for babies born prematurely. The study includes pregnant women between 16 to 42 weeks gestation, particularly those with a history of preterm birth or other risk factors. The MRI scans will provide detailed images that could help predict adverse outcomes and guide clinical decisions.
Who should consider this trial
Good fit: Ideal candidates include pregnant women with uncomplicated pregnancies or those at high risk of preterm birth before 32 weeks gestation.
Not a fit: Patients with multiple pregnancies, gestational diabetes, pre-eclampsia, or known fetal abnormalities may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to earlier interventions and improved health outcomes for babies at risk of preterm birth.
How similar studies have performed: Other studies have shown promise in using MRI for fetal assessment, but this specific approach to predict preterm birth complications is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * pregnant women with uncomplicated pregnancies 16-42 weeks pregnant OR * pregnant women at high risk of preterm birth before 32 weeks gestation Exclusion Criteria: * inability to give informed consent * multiple pregnancy * gestational diabetes * pre-eclampsia * fetuses known to have chromosomal or fetal abnormalities * a recently sited maternal metallic implant, claustrophobia.
Where this trial is running
London, Greater London
- St Thomas' Hospital, King's College London — London, Greater London, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Lisa Story, MD PhD
- Email: lisa.story@kcl.ac.uk
- Phone: 020 7188 7083
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.