Using eye imaging to study blood vessel changes in patients with high blood pressure and kidney disease
Official title: Assessment of Retinal Vasculature Using Optical Coherence Tomography in Health, Hypertension & Chronic Kidney Disease.
Run by University of Edinburgh · NCT02132741 · Data updated 2026-11-12
This study is testing if eye imaging can help show changes in blood vessels for people with high blood pressure and kidney disease compared to healthy individuals.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | University of Edinburgh Academic / other |
| Locations | 1 site (Edinburgh, Midlothian) |
| Status | Recruiting |
| Started | May 16, 2014 |
| Main results expected | December 31, 2027 |
| Study ends | September 2028 |
| Registry record updated | May 13, 2026 |
| Trial ID | NCT02132741 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18-80 with hypertension and/or chronic kidney disease.
✕Probably not a fit
Patients with significant eye disease or those who have had recent eye surgery may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the relationship between hypertension, chronic kidney disease (CKD), and changes in the eye's blood vessels using optical coherence tomography (OCT). By comparing images of the retinal and choroidal structures in patients with hypertension and CKD to those of healthy individuals, the study seeks to determine if OCT can effectively detect vascular changes. The non-invasive nature of OCT allows for quick and easy image acquisition, facilitating recruitment at the Royal Infirmary of Edinburgh. The findings may provide insights into how treating hypertension and CKD could improve vascular health.
Why it matters
Potential benefit: If successful, this study could enhance understanding of vascular health in patients with hypertension and CKD, potentially leading to improved treatment strategies.
How similar studies have gone: While the use of OCT in this context is relatively novel, similar studies have shown promise in detecting vascular changes in other populations.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or female * Age 18-80 * Body mass index ≤35 * For those with hypertension: BP ≥140/90 or on treatment for hypertension * For those with CKD: CKD as defined by the Kidney Diseases Quality Initiative guidelines Exclusion Criteria: * Subject is below the age of legal consent, or is mentally or legally incapacitated * The subject has donated blood (450 ml) within the last 4 weeks * Past or present drug or alcohol abuse including intravenous drug abuse at any time * Participation in another clinical trial within 1 month * Considered to be at high risk of HIV or hepatitis B * Patients with known eye disease, or previous eye surgery, or refractive error greater than +/- 6 dioptres.
Where it's running
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University of Edinburgh
Edinburgh, Midlothian, United Kingdom Recruiting
Study contacts
- Principal investigator: Neeraj Dhaun, MD PhD — University of Edinburgh
- Study coordinator: Neeraj Dhaun, MD PhD
- Email: bean.dhaun@ed.ac.uk
- Phone: 01312429215
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.