Using Erythropoietin to Preserve Alveolar Ridge After Tooth Extraction

Evaluation of Erythropoietin on Alveolar Ridge Preservation: (A Randomized Controlled Clinical Trial With Histomorphometric Assessment)

This study is testing if a medication called Erythropoietin can help keep the jawbone strong after tooth extraction for young adults with teeth that need to be removed.

Quick facts

• Phase: Phase 4
• Study type: Interventional
• Enrollment: 15 (estimated)
• Ages: 18 Years to 40 Years
• Sex: All
• Sponsor: Ain Shams University (Academic / other)
• Locations: 1 site (Cairo)
• Trial ID: NCT06513039 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the effectiveness of Erythropoietin (EPO) in preserving the alveolar ridge following tooth extraction. The study aims to assess dimensional changes of the ridge both clinically and radiographically, while also monitoring postoperative pain, wound healing, and bone regeneration patterns. Patients aged 18-40 with hopeless teeth indicated for extraction will be randomly assigned to receive EPO or a control treatment. The trial is conducted at Ain Shams University and the British University of Egypt, ensuring ethical standards are met through informed consent.

Who should consider this trial

Good fit: Ideal candidates are healthy adults aged 18-40 with teeth that are deemed hopeless and require extraction.

Not a fit: Patients who smoke, are pregnant or lactating, or have occlusal trauma at the extraction site may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could significantly reduce bone loss after tooth extraction, improving outcomes for dental implants and prosthetics.

How similar studies have performed: Previous studies have shown promising results with Erythropoietin in bone regeneration, suggesting potential success for this approach.

Eligibility criteria

Inclusion Criteria:

1. Age range (18-40).
2. Hopeless teeth indicated for extraction such as root fractures, caries, internal root resorption, external root resorption, endodontic failures.
3. Systemically free patients using Cornell Medical Index-Health Questionnaire \[36\].
4. Patients diagnosed with intact surrounding alveolar bone (socket type I) \[37\].
5. Maxillary anterior teeth and/or premolars indicated for extraction.
6. Enough zone of keratinized tissue (≥2 mm).

Exclusion Criteria:

1. Smokers
2. Occlusal trauma at the site of the graft
3. Pregnancy and lactation
4. Bad compliance with the plaque control instructions following initial therapy.

Where this trial is running

Cairo

• Faculty of Dentistry Ain Shams University — Cairo, Egypt (Recruiting)

Study contacts

• Study coordinator: Marwa El Kassaby

Conditions Alveolar Bone Loss