Using Enstilar with Enbrel or Humira for treating plaque psoriasis
Official title: An Open-Label Study Evaluating Enstilar® (Calcipotriene and Betamethasone Dipropionate) Foam, 0.005%/0.064% QD in Psoriasis Patients Being Treated With Etanercept or Adalimumab
Run by Psoriasis Treatment Center of Central New Jersey · NCT03827876 · Data updated 2026-11-12
This study is testing if using a foam treatment called Enstilar along with Enbrel or Humira can help people with chronic plaque psoriasis improve their skin condition.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Psoriasis Treatment Center of Central New Jersey Academic / other |
| Drugs / interventions | adalimumab |
| Locations | 1 site (East Windsor, New Jersey) |
| Status | Recruiting |
| Started | January 16, 2019 |
| Main results expected | September 15, 2019 |
| Study ends | December 15, 2019 |
| Registry record updated | February 4, 2019 |
| Trial ID | NCT03827876 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older with chronic plaque psoriasis affecting 2-10% of their body surface area who have been treated with etanercept or adalimumab for at least 24 weeks.
✕Probably not a fit
Patients with less than 2% or more than 10% body surface area involvement, or those not receiving etanercept or adalimumab for the required duration, will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effectiveness of Enstilar, a topical foam, when used in conjunction with etanercept (Enbrel) or adalimumab (Humira) for patients with chronic plaque psoriasis. Participants will receive Enstilar once daily for the first four weeks, followed by every other day for an additional twelve weeks. The study focuses on patients who have been on etanercept or adalimumab for at least 24 weeks and have a body surface area involvement of 2-10%. The goal is to assess improvements in skin condition and overall patient assessment.
Why it matters
Potential benefit: If successful, this approach could enhance treatment outcomes for patients with plaque psoriasis who are already on systemic therapies.
How similar studies have gone: While there have been studies on the individual effectiveness of Enstilar and systemic therapies, this specific combination approach is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or female adult ≥ 18 years of age; * Diagnosis of chronic plaque-type * Patient with 2-10% BSA * Physician Global Assessment of 2 or greater * Patient has been treated with etanercept or adalimumab for a minimum of 24 weeks Exclusion Criteria: * ˂2 or \>10% BSA * PGA \<2 * Patient not receiving etanercept or adalimumab, or receiving etanercept or adalimumab \<24weeks
Where it's running
-
Psoriasis Treatment Center of Central New Jersey
East Windsor, New Jersey, United States Recruiting
Study contacts
- Study coordinator: Jerry Bagel, MD
- Email: dreamacres1@aol.com
- Phone: 6094434500
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
HB0017 Injection safety and PK in low-weight adults at different injection sites
This early-phase study tests a single subcutaneous HB0017 injection in healthy, low-weight adults and compares how the body processes the drug when injected at different sites.
-
MK-8644: first-in-human test in healthy people and people with psoriasis
This early-phase study tests MK-8644 versus placebo in healthy volunteers and people with psoriasis to see if it is safe and tolerable.
-
Add-on anti-inflammatory therapy for adults with depression and high inflammation
This study tests whether adalimumab, given with your regular antidepressant Lexapro, can improve depressive symptoms in adults with major depressive disorder and high inflammation.
-
Colonic delivery of two antibodies to see if they reach the bloodstream in healthy people
This early study tests whether guselkumab and adalimumab given directly into the colon can enter the body in healthy adults.
-
Is XJH05 Ointment Effective for Plaque Psoriasis?
This study tests whether the XJH05 ointment can help people with plaque psoriasis compare to a calcipotriol ointment.
-
Guselkumab after Ustekinumab in adults with moderate-to-severe psoriasis in routine care
This study looks at how well guselkumab works for people with moderate-to-severe psoriasis after switching from ustekinumab in everyday clinical practice.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.