Clinical trial Recruiting at 1 site Phase 4 Interventional Ages 18 and up

Using Enstilar with Enbrel or Humira for treating plaque psoriasis

Official title: An Open-Label Study Evaluating Enstilar® (Calcipotriene and Betamethasone Dipropionate) Foam, 0.005%/0.064% QD in Psoriasis Patients Being Treated With Etanercept or Adalimumab

Run by Psoriasis Treatment Center of Central New Jersey · NCT03827876 · Data updated 2026-11-12

This study is testing if using a foam treatment called Enstilar along with Enbrel or Humira can help people with chronic plaque psoriasis improve their skin condition.

Quick facts

PhasePhase 4
Study typeInterventional
Ages18 Years and up
SexAll
Enrollment30 (estimated)
SponsorPsoriasis Treatment Center of Central New Jersey
Academic / other
Drugs / interventionsadalimumab
Locations1 site (East Windsor, New Jersey)
StatusRecruiting
StartedJanuary 16, 2019
Main results expectedSeptember 15, 2019
Study endsDecember 15, 2019
Registry record updatedFebruary 4, 2019
Trial IDNCT03827876 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and older with chronic plaque psoriasis affecting 2-10% of their body surface area who have been treated with etanercept or adalimumab for at least 24 weeks.

Probably not a fit

Patients with less than 2% or more than 10% body surface area involvement, or those not receiving etanercept or adalimumab for the required duration, will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of Enstilar, a topical foam, when used in conjunction with etanercept (Enbrel) or adalimumab (Humira) for patients with chronic plaque psoriasis. Participants will receive Enstilar once daily for the first four weeks, followed by every other day for an additional twelve weeks. The study focuses on patients who have been on etanercept or adalimumab for at least 24 weeks and have a body surface area involvement of 2-10%. The goal is to assess improvements in skin condition and overall patient assessment.

Why it matters

Potential benefit: If successful, this approach could enhance treatment outcomes for patients with plaque psoriasis who are already on systemic therapies.

How similar studies have gone: While there have been studies on the individual effectiveness of Enstilar and systemic therapies, this specific combination approach is novel and has not been extensively tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Male or female adult ≥ 18 years of age;
* Diagnosis of chronic plaque-type
* Patient with 2-10% BSA
* Physician Global Assessment of 2 or greater
* Patient has been treated with etanercept or adalimumab for a minimum of 24 weeks

Exclusion Criteria:

* ˂2 or \>10% BSA
* PGA \<2
* Patient not receiving etanercept or adalimumab, or receiving etanercept or adalimumab \<24weeks

Where it's running

  • Psoriasis Treatment Center of Central New Jersey
    East Windsor, New Jersey, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.