Using endoscopic submucosal dissection for early gastrointestinal cancer treatment in the UK
Official title: Endoscopic Submucosal Dissection in the Treatment of Early Gastrointestinal Neoplasia: A UK Cohort Study to Assess Effectiveness and Safety
Run by Portsmouth Hospitals NHS Trust · NCT03039309 · Data updated 2026-11-12
This study is testing whether a special procedure called endoscopic submucosal dissection can effectively treat early gastrointestinal cancer and what the results are for patients in the UK.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Portsmouth Hospitals NHS Trust Government |
| Locations | 1 site (Portsmouth) |
| Status | Recruiting |
| Started | August 5, 2016 |
| Main results expected | August 5, 2028 |
| Study ends | August 5, 2028 |
| Registry record updated | September 17, 2026 |
| Trial ID | NCT03039309 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who are undergoing endoscopic submucosal dissection for early gastrointestinal neoplasia.
✕Probably not a fit
Patients under the age of 18 or those unable to provide informed consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicentre cohort study focuses on the application of endoscopic submucosal dissection (ESD) for treating early gastrointestinal neoplasia. Data will be collected from various centers regarding en bloc resection, curative resection, R0 resection rates, and any complications or adverse events over a two-year follow-up period. Additionally, demographic information and details about the size and location of the lesions will be documented to better understand the outcomes associated with ESD.
Why it matters
Potential benefit: If successful, this study could improve treatment outcomes for patients with early gastrointestinal neoplasia by providing insights into the effectiveness and safety of endoscopic submucosal dissection.
How similar studies have gone: Other studies have shown promising results with endoscopic submucosal dissection for early gastrointestinal neoplasia, indicating that this approach is supported by prior evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or Female, aged 18 years or above undergoing endoscopic submucosal dissection * Participant is able to give informed consent for participation in the study Exclusion Criteria: * Patients under the age of 18 * Patients unable to give informed consent
Where it's running
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Portsmputh Hospitals NHS Trust
Portsmouth, United Kingdom Recruiting
Study contacts
- Principal investigator: Prof Pradeep Bhandari, MBBS, MD — Portsmouth Hospitals NHS Trust
- Study coordinator: Prof Pradeep Bhandari, MBBS, MD
- Email: pradeep.bhandari@porthosp.nhs.uk
- Phone: 02392286000
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Using a robotic system to improve safety and efficiency in treating early gastric cancer
This study is testing if a new robotic system can make the treatment for early gastric cancer safer and quicker compared to the usual method.
-
Using a new bipolar knife for removing esophageal lesions
This study is testing a new type of tool for safely removing esophageal growths in patients with precancerous lesions to see if it works better than older methods.
-
Exploring how dissection depth affects scar formation in early gastric cancer treatment
This study is testing how the depth of a specific surgery for early gastric cancer affects scar size and healing in patients.
-
Endoscopic removal of cancerous and precancerous lesions in the digestive tract
This project looks back at adults who had endoscopic removal of upper or lower digestive tract tumors to see which resection techniques worked best and were safest.
-
Evaluating the clinical utility of Endoscopic Submucosal Dissection
This study looks at how helpful Endoscopic Submucosal Dissection is for patients who are already scheduled to have the procedure as part of their regular medical care.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.