Using end-tidal CO2 levels to predict post-operative complications in vascular surgery patients
Rest PETCO2 As a Predictor of Post-operative Complications in Patient Undergoing Major Vascular Surgery
This study is testing if measuring carbon dioxide levels in the breath before major vascular surgery can help predict complications after the surgery for older patients with health issues.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 130 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | St. Anne's University Hospital Brno, Czech Republic Academic / other |
| Locations | 1 site (Brno, Czech Republic) |
| Trial ID | NCT05861089 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the relationship between resting end-tidal carbon dioxide (PETCO2) levels and the occurrence of post-operative complications in patients undergoing major vascular surgery. Given that many elderly patients with significant comorbidities are unable to complete traditional cardiopulmonary exercise testing (CPET), this study seeks to identify a simpler and effective alternative for risk assessment. By measuring PETCO2 before surgery, the researchers hope to determine if low levels are predictive of complications such as pulmonary and cardiovascular issues following surgery. The findings could provide valuable insights into preoperative risk stratification for this vulnerable patient population.
Who should consider this trial
Good fit: Ideal candidates for this study are elderly patients scheduled for major vascular surgery who are unable to undergo traditional CPET.
Not a fit: Patients with a tracheostomy will not benefit from this study due to exclusion criteria.
Why it matters
Potential benefit: If successful, this approach could offer a non-invasive method for predicting post-operative complications, improving patient outcomes and surgical planning.
How similar studies have performed: Previous studies have shown that PETCO2 can predict complications in lung resection surgery, suggesting potential applicability in vascular surgery, although this specific approach is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * indication for major vascular surgery (aortobifemoral bypass surgery) Exclusion Criteria: * tracheostomy
Where this trial is running
Brno, Czech Republic
- St. Anne's University Hospital in Brno — Brno, Czech Republic, Czechia (Recruiting)
Study contacts
- Principal investigator: Ivan Cundrle, MD, PhD — St. Anne's University Hospital
- Study coordinator: Ivan Cundrle, MD, PhD
- Email: cundrle@fnusa.cz
- Phone: +420543182553
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.