Using electrical stimulation to improve motor function in stroke patients
The Effects of Bilateral-Transcranial Electrical Stimulation (tES) on Cortical Activity, Motor Performances, and Cognitive Function in Sub-Acute and Chronic Stroke Individuals
This study is testing if using electrical stimulation along with regular physical therapy can help improve movement and brain function in people recovering from a stroke.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 42 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Mahidol University Academic / other |
| Locations | 1 site (Salaya, Nakonpathom) |
| Trial ID | NCT06134921 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of transcranial electrical stimulation (tES) combined with conventional physical therapy on motor function and cortical activity in individuals recovering from stroke. Participants will include those with sub-acute to chronic stroke, specifically within 2 weeks to 2 years post-stroke. The study aims to assess improvements in upper and lower limb motor function and brain activity, potentially enhancing rehabilitation outcomes for stroke survivors. The interventions include active tES techniques and a sham stimulation for comparison.
Who should consider this trial
Good fit: Ideal candidates are stroke survivors aged 18 to 80 who have experienced a first-ever unilateral ischemic or hemorrhagic stroke and are within 2 weeks to 2 years post-stroke.
Not a fit: Patients with neurological antecedents, unstable medical conditions, or those who have received non-invasive brain stimulation in the past 6 months may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve motor function and rehabilitation outcomes for stroke patients.
How similar studies have performed: Other studies have shown promise in using electrical stimulation for stroke rehabilitation, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Stroke individuals aged 18 - 80 years. 2. A first-ever unilateral ischemic or hemorrhagic stroke. 3. Stroke onset from at least 2 weeks - 2 years. 4. Having modified Rankin scale (mRS) 1-4 5. Ability to communicate, follow, and understand the instruction. Exclusion Criteria: 1. Presence of any neurological antecedent, unstable medical conditions or condition that may increase risk of stimulation such as epilepsy and seizure, and history of brain surgery. 2. Presence of metal implantation, intracranial shunt, cochlear implantation, or cardiac pacemakers. 3. Presence of opened wound or infectious wound around the scalp. 4. Moderate pain in any joint of the upper or lower paretic limb (numerical pain rating score \> 4/10). 5. History of receiving non-invasive brain stimulation within the past 6 months.
Where this trial is running
Salaya, Nakonpathom
- Faculty of Physical Therapy, Mahidol University — Salaya, Nakonpathom, Thailand (Recruiting)
Study contacts
- Study coordinator: Wanalee Klomjai, PhD
- Email: wanalee.klo@mahidol.edu
- Phone: +6624415450
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.