Using electrical stimulation to improve cognitive symptoms in Parkinson's disease
Investigation of the Benefits of Electrical Non-invasive Stimulation on Cognitive Symptoms in Parkinson's Disease
This study is testing if a type of electrical stimulation can help improve thinking skills like working memory in people with Parkinson's disease.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Institut National de la Santé Et de la Recherche Médicale, France Government |
| Locations | 1 site (Rennes) |
| Trial ID | NCT05808504 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of non-invasive electrical stimulation on cognitive symptoms associated with Parkinson's disease, particularly focusing on inhibition processes that are crucial for daily behavior adaptation. Participants will undergo neuropsychological and neurological assessments, cognitive tasks, and EEG monitoring while receiving either real or sham transcranial alternating current stimulation (tACS). The goal is to determine if this stimulation can enhance cognitive functions such as working memory in individuals with Parkinson's disease.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 75 with idiopathic Parkinson's disease and no major cognitive impairments.
Not a fit: Patients with severe cognitive impairments or significant motor difficulties may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could provide a new non-invasive treatment option to improve cognitive symptoms in patients with Parkinson's disease.
How similar studies have performed: Previous studies have shown promising results using non-invasive brain stimulation techniques for cognitive enhancement, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: For all participants: * Affiliation to a social security scheme or beneficiary of such a scheme. * Age over 18 years old. * Age less than 75 years old * Correct or correctly corrected view (on simple declaration by the patient). * Subject having received information on the protocol and having provided informed and written consent to participate. Criteria exclusive to patients: \- Idiopathic Parkinson's disease according to United Kingdom Parkinson's criteria Brain Bank disease (Hughes et al., 1992). Exclusion Criteria: For all participants: * Major cognitive impairment (Moca \< 22) or severe neurocognitive disorder according to DSM-V (Diagnostic and statistical manual of mental disorders -V); * Motor difficulties preventing the achievement of the task. * Drug or alcohol addiction. * Adult subject to legal protection (safeguard of justice, curatorship, guardianship), persons deprived of liberty. * Present or past moderate to severe psychiatric pathology (obsessive compulsive, bipolar disorder, schizophrenia, etc.). * Potential for pregnancy or confirmed pregnancy. A pregnancy test will be performed on inclusion.for women of childbearing age. Criteria exclusive to patients: * Present or past neurological pathology other than Parkinson's disease (accident stroke, head trauma, etc.). * Deep brain stimulation treatment. Exclusive to healthy participants: \- Present or past neurological pathology.
Where this trial is running
Rennes
- CHU de Rennes — Rennes, France (Recruiting)
Study contacts
- Principal investigator: Paul Sauleau, MD — Rennes University Hospital
- Study coordinator: Paul Sauleau, MD
- Email: paul.sauleau@chu-rennes.fr
- Phone: +332 99 28 42 58
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.