Using electrical nerve stimulation to treat urinary retention
Efficacy of Electrical Pudendal Nerve Stimulation and Sacral Neuromodulation in Treating Non-obstructive Neurogenic Urinary Retention: A Comparative Study
This study is testing whether a new electrical nerve stimulation method can help people with urinary retention caused by nerve issues feel better compared to a standard treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 75 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | Shanghai Institute of Acupuncture, Moxibustion and Meridian Academic / other |
| Locations | 1 site (Shanghai) |
| Trial ID | NCT06158074 on ClinicalTrials.gov |
What this trial studies
This study aims to compare the effectiveness of electrical pudendal nerve stimulation (EPNS) and sacral neuromodulation (SNM) in treating non-obstructive neurogenic urinary retention. It will evaluate the clinical effects of both interventions and assess the advantages of EPNS as a new treatment method for this condition. The study will involve patients with urinary retention due to various neurological disorders, ensuring they have normal upper urinary tract function. Participants will be monitored for their response to the treatments over a specified follow-up period.
Who should consider this trial
Good fit: Ideal candidates include individuals with non-mechanical obstructive urinary retention due to neurological disorders and normal upper urinary tract function.
Not a fit: Patients with significant symptom improvement from other therapies or those with certain neurological lesions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a new effective treatment option for patients suffering from neurogenic urinary retention.
How similar studies have performed: While the specific combination of EPNS and SNM is being evaluated, similar approaches in neuromodulation have shown promise in other studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Non-mechanical obstructive urinary retention occurs following relevant neurological system disorders (spinal cord injury, spina bifida，myelitis, cervical/thoracic disk disease, lesion following spinal anesthesia/spine surgery,lumbar/sacral spine intervertebral disc diseases, spinal stenosis, iatrogenic pelvic nerve lesions, sacral agenesis, peripheral neuropathy due to diabetes mellitus). * With normal upper urinary tract function. * Other therapies and medications potentially affecting the assessment of this therapy have been discontinued for at least two weeks before the interventional procedure. * Patient with good compliance who is capable of cooperating with the follow-up requirements Exclusion Criteria: * Patients with any suprapontine and pontine lesions * Pregnant or lactating women * Individuals whose symptoms show significant improvement after pharmaceutical and adjunctive therapy * Individuals with concurrent acute or chronic prostatitis, prostate cancer, or conditions such as bladder neck stenosis, urethral stricture, or urethral injury * High pathological risk factors (e.g., lymph node metastasis, resection margin involvement, bulky tumors) * Individuals with concomitant obstructive urinary retention
Where this trial is running
Shanghai
- Shanghai research institute of acupuncture and meridian — Shanghai, China (Recruiting)
Study contacts
- Study coordinator: Siyou Wang, M.M.
- Email: wangsiyou1234@163.com
- Phone: 86 13916145984
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.