Using EEG to predict postoperative delirium in neurosurgery patients
Frontal-temporal EEG During Anesthesia Recovery Predicts Postoperative Delirium in Neurosurgery: a Single-center, Prospective, Observational Study
This study is testing if monitoring brain activity with EEG can help doctors predict if adults will experience confusion after having brain surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 137 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Beijing Sanbo Brain Hospital Academic / other |
| Locations | 2 sites (Beijing, Beijing Municipality and 1 other locations) |
| Trial ID | NCT06894238 on ClinicalTrials.gov |
What this trial studies
This observational study aims to determine if sub-hairline electroencephalography (EEG) can reliably predict postoperative delirium (POD) in adult patients undergoing elective craniotomy. Patients will have their EEG monitored during the immediate recovery phase in the ICU, focusing on specific brain regions and frequency bands. The study seeks to identify EEG parameters that correlate with the onset of POD, which is a common complication following major neurosurgery. By understanding these predictive markers, the study hopes to improve early identification and management of at-risk patients.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older scheduled for elective neurosurgical procedures with ASA physical status I-II.
Not a fit: Patients with known neurological or psychiatric disorders, preoperative cognitive impairment, or those unable to undergo EEG monitoring due to specific conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection and management of postoperative delirium, enhancing patient outcomes and reducing healthcare costs.
How similar studies have performed: While EEG has been used in various settings, the specific application of sub-hairline EEG for predicting postoperative delirium in neurosurgical patients is largely novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years * Planned elective neurosurgical surgery * ASA physical status I-II * Signed informed consent Exclusion Criteria: * Known neurological or psychiatric disorders (e.g., epilepsy, Parkinson's disease) * Preoperative cognitive impairment (MMSE score \< 24) * Long-term use of central nervous system drugs (e.g., antidepressants, antipsychotics) * Language barriers * History of craniotomy within the last 12 months * Inability to place frontal-temporal electrodes due to conditions such as frontal skin injury, severe agitation, or a coronal incision for surgery * Pregnant or breastfeeding women
Where this trial is running
Beijing, Beijing Municipality and 1 other locations
- Beijing Sanbo Brain Hospital, Capital Medical University — Beijing, Beijing Municipality, China (Recruiting)
- Sanbo Brain Hospital, Captial Medical Universtiy — Beijing, Beijing Municipality, China (Recruiting)
Study contacts
- Principal investigator: Zhonghua Shi, PhD,MD — Capital Medical University
- Study coordinator: Zhonghua Shi, PhD,MD
- Email: z.shi@mail.ccmu.edu.cn
- Phone: 010-62856764
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.