Using ECMO for patients with refractory out-of-hospital cardiac arrest
Prognosis of Refractory Out-of-hospital Cardiac Arrests Treated With Extracorporeal Cardiopulmonary Resuscitation (ECMO) by the Urgent Medical Aid Service (SAMU) of Paris
This study is testing if a special heart-lung machine can help adults who have had a cardiac arrest outside of the hospital survive and have a better quality of life after a year.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 840 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Trial ID | NCT06397417 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the effectiveness of extracorporeal cardiopulmonary resuscitation (ECPR) in patients experiencing refractory out-of-hospital cardiac arrest. Conducted by the ECMO team of the Paris SAMU, the study will establish a prospective registry over 20 years, focusing on patients over 18 years old who have undergone ECMO treatment. The study will measure the one-year survival rate, assess functional prognosis, and analyze factors associated with outcomes. Data collection will include long-term cardiac function and other relevant health metrics.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 who have experienced a non-traumatic refractory out-of-hospital cardiac arrest and received ECMO treatment.
Not a fit: Patients under 18 years old or those who do not receive ECMO treatment will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve survival rates and functional outcomes for patients experiencing refractory cardiac arrest.
How similar studies have performed: Other studies have shown promising results with ECPR in similar contexts, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients who have benefited from an installation or attempted installation of an extracorporeal membrane oxygenation (ECMO) device following a non-traumatic refractory cardiac arrest as part of the ECMO TEAM of the Samu de Paris during the time of the study. * Obtaining non-opposition from the patient or a relative in the event of the patient's death or a lasting state of health preventing them from becoming aware of the study. Exclusion Criteria: \- Minor patients
Where this trial is running
Paris
- Hôpital Necker-Enfants Malades — Paris, France (Recruiting)
Study contacts
- Principal investigator: Jean-Herlé Raphalen, MD — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Jean-Herlé Raphalen, MD
- Email: jena-herle.raphalen@aphp.fr
- Phone: 1 87 89 29 63
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.