Using ECMO for patients with refractory out-of-hospital cardiac arrest
Official title: Prognosis of Refractory Out-of-hospital Cardiac Arrests Treated With Extracorporeal Cardiopulmonary Resuscitation (ECMO) by the Urgent Medical Aid Service (SAMU) of Paris
Run by Assistance Publique - Hôpitaux de Paris · NCT06397417 · Data updated 2026-11-12
This study is testing if a special heart-lung machine can help adults who have had a cardiac arrest outside of the hospital survive and have a better quality of life after a year.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 840 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | March 5, 2025 |
| Main results expected | March 2046 |
| Study ends | March 2046 |
| Registry record updated | September 12, 2025 |
| Trial ID | NCT06397417 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 18 who have experienced a non-traumatic refractory out-of-hospital cardiac arrest and received ECMO treatment.
✕Probably not a fit
Patients under 18 years old or those who do not receive ECMO treatment will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to evaluate the effectiveness of extracorporeal cardiopulmonary resuscitation (ECPR) in patients experiencing refractory out-of-hospital cardiac arrest. Conducted by the ECMO team of the Paris SAMU, the study will establish a prospective registry over 20 years, focusing on patients over 18 years old who have undergone ECMO treatment. The study will measure the one-year survival rate, assess functional prognosis, and analyze factors associated with outcomes. Data collection will include long-term cardiac function and other relevant health metrics.
Why it matters
Potential benefit: If successful, this study could improve survival rates and functional outcomes for patients experiencing refractory cardiac arrest.
How similar studies have gone: Other studies have shown promising results with ECPR in similar contexts, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients who have benefited from an installation or attempted installation of an extracorporeal membrane oxygenation (ECMO) device following a non-traumatic refractory cardiac arrest as part of the ECMO TEAM of the Samu de Paris during the time of the study. * Obtaining non-opposition from the patient or a relative in the event of the patient's death or a lasting state of health preventing them from becoming aware of the study. Exclusion Criteria: \- Minor patients
Where it's running
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Hôpital Necker-Enfants Malades
Paris, France Recruiting
Study contacts
- Principal investigator: Jean-Herlé Raphalen, MD — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Jean-Herlé Raphalen, MD
- Email: jena-herle.raphalen@aphp.fr
- Phone: 1 87 89 29 63
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Prehospital access to extracorporeal cardiopulmonary resuscitation in Prague
This study is testing if a special emergency treatment called prehospital extracorporeal cardiopulmonary resuscitation (ECPR) can help people who have a cardiac arrest outside of the hospital survive better and have better brain function compared to those who only get treatment in the hospital.
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Minimal Sedation After Out-of-Hospital Cardiac Arrest
This study tests whether stopping continuous sedation right after return of circulation is as safe as keeping patients sedated in the early hours after OHCA.
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Super-Early Neuroprognostication in eCPR Patients
This observational study tests whether rapid brain-status measurements taken early after ECMO initiation can help predict neurological outcomes in adults considered for eCPR.
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Drone delivery of AEDs to bystanders for out-of-hospital cardiac arrest
This project will test whether drones can deliver AEDs quickly to bystanders helping someone who has a cardiac arrest outside a hospital.
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Pre-hospital wearable cooling after out-of-hospital cardiac arrest
This pilot test tries a battery-free CarbonCool® cooling vest applied by paramedics to adults who regain a pulse after out-of-hospital cardiac arrest but remain unconscious to see if early cooling is feasible and safe.
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Early double sequential defibrillation for cardiac arrest outside the hospital
We test whether using two defibrillators in quick succession after the first failed shock helps adults with out‑of‑hospital cardiac arrest and a shockable rhythm survive more often than continuing standard single shocks.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.