Using echocardiography to improve outcomes in heart failure patients receiving cardiac resynchronization therapy
Prediction of Response to Cardiac Resynchronization Therapy by New Echocardiographic Methods
This study is trying to see if using special heart imaging techniques can help doctors better understand how heart failure patients with a specific heart condition respond to a treatment called cardiac resynchronization therapy.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Lille Catholic University Academic / other |
| Locations | 1 site (Lomme) |
| Trial ID | NCT02986633 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify echocardiographic parameters linked to the response and outcomes of cardiac resynchronization therapy (CRT) in patients with heart failure and reduced left ventricular ejection fraction. It focuses on patients with Left Bundle Branch Block (LBBB) and utilizes advanced echocardiographic techniques, such as speckle tracking strain, to assess contractile abnormalities. By understanding these parameters, the study seeks to improve the predictive value of CRT response and enhance patient outcomes. The study will involve monitoring patients who meet specific eligibility criteria related to heart failure severity and CRT indications.
Who should consider this trial
Good fit: Ideal candidates for this study are patients with heart failure, a left ventricular ejection fraction of less than 35%, and a QRS duration greater than 120 ms.
Not a fit: Patients with rhythmologic indications for CRT due to atrial fibrillation or those with a left ventricular ejection fraction between 35% and 45% may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved patient selection for CRT, enhancing treatment outcomes for heart failure patients.
How similar studies have performed: While the approach of using advanced echocardiographic techniques in CRT is promising, the specific predictive value of LBBB-related contractile abnormalities remains to be fully established, indicating a novel aspect of this research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Heart failure with left ventricular ejection fraction less than 35 % * QRS duration over than 120 ms * Clinical indication for CRT Exclusion Criteria: * Rythmologic indication of CRT for atrial fibrillation control * Rythmologic indication of CRT for left ventricular ejection fraction between 35% and 45%
Where this trial is running
Lomme
- Hospitals of Lille Catholic University (GHICL) — Lomme, France (Recruiting)
Study contacts
- Principal investigator: Sylvestre Maréchaux, MD, PhD — Hospital of Lille Catholic University (GHICL)
- Study coordinator: Amélie Lansiaux, MD, PhD
- Email: lansiaux.amelie@ghicl.net
- Phone: 00 33 3 20 52 69
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.