Using echocardiography to improve outcomes in heart failure patients receiving cardiac resynchronization therapy
Official title: Prediction of Response to Cardiac Resynchronization Therapy by New Echocardiographic Methods
Run by Lille Catholic University · NCT02986633 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is trying to see if using special heart imaging techniques can help doctors better understand how heart failure patients with a specific heart condition respond to a treatment called cardiac resynchronization therapy.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Lille Catholic University Academic / other |
| Locations | 1 site (Lomme) |
| Trial ID | NCT02986633 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients with heart failure, a left ventricular ejection fraction of less than 35%, and a QRS duration greater than 120 ms.
✕Probably not a fit
Patients with rhythmologic indications for CRT due to atrial fibrillation or those with a left ventricular ejection fraction between 35% and 45% may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to identify echocardiographic parameters linked to the response and outcomes of cardiac resynchronization therapy (CRT) in patients with heart failure and reduced left ventricular ejection fraction. It focuses on patients with Left Bundle Branch Block (LBBB) and utilizes advanced echocardiographic techniques, such as speckle tracking strain, to assess contractile abnormalities. By understanding these parameters, the study seeks to improve the predictive value of CRT response and enhance patient outcomes. The study will involve monitoring patients who meet specific eligibility criteria related to heart failure severity and CRT indications.
Why it matters
Potential benefit: If successful, this study could lead to improved patient selection for CRT, enhancing treatment outcomes for heart failure patients.
How similar studies have gone: While the approach of using advanced echocardiographic techniques in CRT is promising, the specific predictive value of LBBB-related contractile abnormalities remains to be fully established, indicating a novel aspect of this research.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Heart failure with left ventricular ejection fraction less than 35 % * QRS duration over than 120 ms * Clinical indication for CRT Exclusion Criteria: * Rythmologic indication of CRT for atrial fibrillation control * Rythmologic indication of CRT for left ventricular ejection fraction between 35% and 45%
Where it's running
-
Hospitals of Lille Catholic University (GHICL)
Lomme, France Recruiting
Study contacts
- Principal investigator: Sylvestre Maréchaux, MD, PhD — Hospital of Lille Catholic University (GHICL)
- Study coordinator: Amélie Lansiaux, MD, PhD
- Email: lansiaux.amelie@ghicl.net
- Phone: 00 33 3 20 52 69
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This study is testing whether the Aortix device can help people with acute heart failure who aren't responding to diuretics feel better compared to standard treatment.
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Coronary blood flow testing in people with reduced ejection fraction and left bundle branch block after CRT
This work will test whether direct intracoronary measurements of flow and pressure show reduced coronary blood flow in people with low ejection fraction and left bundle branch block who have a CRT device.
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Evaluating His-Bundle Pacing for Heart Failure Treatment
This study is testing if a new heart pacing method can help people with heart failure and a specific heart block feel better compared to the standard treatment.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.