Using dynamic parameters to assess fluid responsiveness in critically ill patients
The Performance of Changes of Pulse Pressure and of Pulse Pressure Variation to Detect Preload Responsiveness in Mechanically Ventilated Patients Under a Spontaneous Mode
This study is testing if certain blood pressure measurements can help doctors figure out which critically ill patients need extra fluids to improve their condition.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | CHU de Reims Academic / other |
| Locations | 1 site (Reims) |
| Trial ID | NCT06495489 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the effectiveness of Pulse Pressure Variation (PPV) and Pulse Pressure (PP) in predicting fluid responsiveness in mechanically ventilated patients under spontaneous mode in intensive care. The study involves measuring arterial pressure continuously and assessing changes during a Passive Leg Raising (PLR) maneuver. By comparing hemodynamic parameters before and after the PLR, the researchers hope to identify patients who will benefit from fluid infusion, thereby improving management of septic shock and other forms of acute circulatory failure.
Who should consider this trial
Good fit: Ideal candidates include critically ill patients over 18 years old, hospitalized in intensive care, and requiring assessment of fluid responsiveness due to acute circulatory failure.
Not a fit: Patients with arrhythmias, intra-abdominal hypertension, or contraindications to the PLR maneuver will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate predictions of fluid responsiveness, potentially improving outcomes for critically ill patients.
How similar studies have performed: Previous studies have shown promise in using dynamic parameters for fluid responsiveness, but this specific approach is being evaluated in a novel context.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient over 18 years old. * Hospitalized in intensive care. * For which the clinician in charge of the patient will need to predict the response to fluids and decide on a possible infusion of fluids, because of: * Acute circulatory failure with mean arterial pressure \< 65mmHg or \< 30mmHg of its baseline value for hypertensive patients. * And/or other signs of hemodynamic instability (tachycardia, mottling, oliguria, hyperlactatemia). * In mechanically ventilated patients under spontaneous mode. * Previously equipped with an arterial catheter. * Affiliated to a social security scheme. Exclusion Criteria: * Patient with arrythmia (PPV is not applicable). * Patient with intra-abdominal hypertension (PLR test is not valid). * Patient with a contraindication/impossibility to the PLR maneuver (lower limb amputation, respiratory intolerance). * Patient with poor echogenicity noted previously. * Patient protected by law.
Where this trial is running
Reims
- Chu Reims — Reims, France (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.