Using dried blood spots to monitor vancomycin and creatinine levels for outpatient antibiotic therapy
A Dried Blood Spot Sampling Method for Vancomycin and Creatinine Monitoring: Effectiveness Demonstrated in Outpatient Parenteral Antibiotic Therapy Service
This study is testing a new way to check vancomycin and creatinine levels using a small drop of blood from a finger prick to make it easier for patients on outpatient antibiotic therapy.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 84 (estimated) |
| Ages | 18 Years to 120 Years |
| Sex | All |
| Sponsor | Erasmus Medical Center Academic / other |
| Locations | 1 site (Rotterdam) |
| Trial ID | NCT06283433 on ClinicalTrials.gov |
What this trial studies
This study evaluates a new method for monitoring vancomycin and creatinine levels in patients receiving outpatient parenteral antibiotic therapy (OPAT) using dried blood spot (DBS) sampling. The DBS method involves collecting a small drop of blood from a finger prick, which is less invasive and more convenient than traditional venipuncture. By implementing this technique, the study aims to reduce the burden of frequent hospital visits for blood sampling, thereby improving patient comfort and compliance. The study will assess the effectiveness and feasibility of this innovative approach in a clinical setting.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and over who are hospitalized and will be discharged to receive outpatient vancomycin therapy.
Not a fit: Patients with cognitive dysfunction or those unable to perform finger pricks or complete questionnaires may not benefit from this study.
Why it matters
Potential benefit: If successful, this method could significantly enhance patient comfort and adherence to treatment by minimizing the need for hospital visits.
How similar studies have performed: Other studies have shown promise with similar dried blood spot techniques, indicating potential for success in this novel application.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 18 and over * Able to understand written information and able to give informed consent * Hospitalized * Treated with intravenous vancomycin and to be discharged with vancomycin OPAT service with minimal 1 planned outpatient vancomycin TDM order * Able and willing to perform finger pricks for dried blood spot sampling, or able and willing to undergo finger pricks performed by family members or other caregivers * Able and willing to fill in questionnaires Exclusion Criteria: * Former participation in this trial * Cognitive dysfunction or other dysfunctionalities which makes the patient unable to draw blood by a finger prick or fill out questionnaires * Unable to sample an adequate DBS after training in the hospital (this is also applicable for family members or other caregivers who are failing to perform adequate DBS sampling for the patient)
Where this trial is running
Rotterdam
- Erasmus MC — Rotterdam, Netherlands (Recruiting)
Study contacts
- Principal investigator: Birgit Koch, PharmD — Erasmus MC University Medical Center
- Study coordinator: Birgit Koch, PharmD
- Email: b.koch@erasmusmc.nl
- Phone: 0107033202
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.