Using Doppler ultrasound resistive index to distinguish benign and malignant breast masses
Official title: A Novel Approach to the Evaluation of Breast Masses Using Doppler Ultrasonography: Percentage Changes in Resistive Index Between the Mass and Surrounding Normal Parenchyma in Benign-Malignant Differentiation
Run by Karamanoğlu Mehmetbey University · NCT07465523 · Data updated 2026-11-12
This study will test whether comparing Doppler resistive index values from a breast mass and nearby healthy breast tissue can help tell if a solid breast lump in women is benign or malignant.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 90 (estimated) |
| Sponsor | Karamanoğlu Mehmetbey University Academic / other |
| Locations | 1 site (Karaman, Lütfen Seçiniz.) |
| Status | Recruiting |
| Started | March 4, 2026 |
| Main results expected | May 5, 2026 |
| Study ends | May 19, 2026 |
| Registry record updated | March 16, 2026 |
| Trial ID | NCT07465523 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women with solid breast masses who have or will have pathology results (biopsy/surgical pathology) are ideal candidates.
✕Probably not a fit
Patients with cystic or hypovascular lesions, active mastitis, or without confirmatory pathology results are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The study records minimum, maximum, and average Doppler resistive index (RI) values from solid breast masses, adjacent healthy tissue, and the opposite breast, then calculates relative RI differences between mass and healthy tissue. Cases are classified by pathology into benign and malignant groups and threshold RI differences that separate these groups will be determined. In addition, vascular index measurements using Doppler Microvascular Flow imaging will be calculated for each mass to add microvascular information. The design is observational and excludes cystic or hypovascular masses and cases with mastitis.
Why it matters
Potential benefit: If successful, this approach could improve noninvasive differentiation of benign and malignant breast masses and potentially reduce unnecessary biopsies.
How similar studies have gone: Prior Doppler RI studies have shown mixed but promising results for distinguishing benign from malignant lesions, and combining relative RI differences with Doppler Microvascular Flow is a relatively newer approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Those with solid breast masses * Female patients * Those with pathology results Exclusion Criteria: * Hypovascular masses * Cystic breast masses * Cases with mastitis
Where it's running
-
Karamanoğlu Mehmetbey University, KEAH
Karaman, Lütfen Seçiniz., Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Ahmet Yeşildağ, Prof.Dr
- Email: ahmetysd@hotmail.com
- Phone: +905057728297
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.