Clinical trial Recruiting at 1 site Observational Ages 18 and up Women only

Using Doppler ultrasound resistive index to distinguish benign and malignant breast masses

Official title: A Novel Approach to the Evaluation of Breast Masses Using Doppler Ultrasonography: Percentage Changes in Resistive Index Between the Mass and Surrounding Normal Parenchyma in Benign-Malignant Differentiation

Run by Karamanoğlu Mehmetbey University · NCT07465523 · Data updated 2026-11-12

This study will test whether comparing Doppler resistive index values from a breast mass and nearby healthy breast tissue can help tell if a solid breast lump in women is benign or malignant.

More Breast Neoplasm Female trials

Quick facts

Study typeObservational
Ages18 Years and up
SexWomen only
Enrollment90 (estimated)
SponsorKaramanoğlu Mehmetbey University
Academic / other
Locations1 site (Karaman, Lütfen Seçiniz.)
StatusRecruiting
StartedMarch 4, 2026
Main results expectedMay 5, 2026
Study endsMay 19, 2026
Registry record updatedMarch 16, 2026
Trial IDNCT07465523 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Women with solid breast masses who have or will have pathology results (biopsy/surgical pathology) are ideal candidates.

Probably not a fit

Patients with cystic or hypovascular lesions, active mastitis, or without confirmatory pathology results are unlikely to benefit from this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study records minimum, maximum, and average Doppler resistive index (RI) values from solid breast masses, adjacent healthy tissue, and the opposite breast, then calculates relative RI differences between mass and healthy tissue. Cases are classified by pathology into benign and malignant groups and threshold RI differences that separate these groups will be determined. In addition, vascular index measurements using Doppler Microvascular Flow imaging will be calculated for each mass to add microvascular information. The design is observational and excludes cystic or hypovascular masses and cases with mastitis.

Why it matters

Potential benefit: If successful, this approach could improve noninvasive differentiation of benign and malignant breast masses and potentially reduce unnecessary biopsies.

How similar studies have gone: Prior Doppler RI studies have shown mixed but promising results for distinguishing benign from malignant lesions, and combining relative RI differences with Doppler Microvascular Flow is a relatively newer approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Those with solid breast masses
* Female patients
* Those with pathology results

Exclusion Criteria:

* Hypovascular masses
* Cystic breast masses
* Cases with mastitis

Where it's running

  • Karamanoğlu Mehmetbey University, KEAH
    Karaman, Lütfen Seçiniz., Turkey (Türkiye)
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.