Using diosmin to reduce muscle soreness after exercise
Evaluation of the Prophylactic Effects of the Flavonoid Diosmin on Delayed-onset Muscle Soreness in Humans: a Randomized, Double-blinded and Placebo-controlled Single-center Clinical Trial
PHASE1 · Universidade Estadual de Londrina · NCT06125002
This study is testing if taking diosmin can help female soccer players feel less muscle soreness after intense exercise.
Quick facts
| Phase | PHASE1 |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 16 Years to 35 Years |
| Sex | Female |
| Sponsor | Universidade Estadual de Londrina (other) |
| Locations | 1 site (Londrina, Paraná) |
| Trial ID | NCT06125002 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of diosmin, a flavonoid, on delayed-onset muscle soreness (DOMS) in female athletes participating in intense dynamic exercise. The study will involve a randomized, double-blinded, and placebo-controlled design, with approximately 40 participants from a women's five-a-side soccer team in Londrina, Brazil. The main objectives include assessing whether diosmin supplementation can alleviate muscle pain, lower serum creatine phosphokinase levels, and improve muscle performance and balance post-exercise.
Who should consider this trial
Good fit: Ideal candidates for this study are female athletes aged 16 to 35 who can perform the specified intense dynamic exercise protocol.
Not a fit: Patients with locomotor system dysfunctions or those using analgesic/anti-inflammatory medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a new approach to managing muscle soreness, enhancing athletes' recovery and adherence to exercise programs.
How similar studies have performed: While the use of flavonoids for muscle soreness is a relatively novel approach, previous studies have shown promising results with similar interventions in other contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Be within the pre-determined age range. * Be able to perform the proposed intense dynamic exercise protocol. Exclusion Criteria: * Locomotor system dysfunctions. * Use of analgesic/anti-inflammatory medication at the time of recruitment. * Calorie-restricted diet or ergogenic supplementation.
Where this trial is running
Londrina, Paraná
- Universidade Estadual de Londrina — Londrina, Paraná, Brazil (RECRUITING)
Study contacts
- Principal investigator: Sergio M Borghi — Universidade Estadual de Londrina
- Study coordinator: Sergio M Borghi, Ph.D.
- Email: sborghi@uel.br
- Phone: +55 43 999189216
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Myalgia, delayed-onset muscle soreness, DOMS, exercise, flavonoids, diosmin